Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma‑1 Receptor Antagonists with Promising Antinociceptive Properties

In an attempt to extend recent studies showing that some clinically evaluated histamine H3 receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we selected 20 representative structures among our previously reported H3R ligands to investigate their affinity at σRs. Most o...

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Veröffentlicht in:	ACS chemical neuroscience 2022-01, Vol.13 (1), p.1-15
Hauptverfasser:	Szczepańska, Katarzyna, Podlewska, Sabina, Dichiara, Maria, Gentile, Davide, Patamia, Vincenzo, Rosier, Niklas, Mönnich, Denise, Ruiz Cantero, M, Karcz, Tadeusz, Łażewska, Dorota, Siwek, Agata, Pockes, Steffen, Cobos, Enrique J, Marrazzo, Agostino, Stark, Holger, Rescifina, Antonio, Bojarski, Andrzej J, Amata, Emanuele, Kieć-Kononowicz, Katarzyna
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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