Conditioning treatment with CD27 Ab enhances expansion and antitumor activity of adoptively transferred T cells in mice

Cyclophosphamide plus fludarabine (C/F) are currently used to improve the expansion and effectiveness of adoptive cell therapy (ACT). However, these chemotherapeutics cause pan-leukopenia and adverse events, suggesting that safer and more effective conditioning treatments are needed to improve ACT o...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2022-01, Vol.71 (1), p.97-109
Hauptverfasser:	Wasiuk, Anna, Weidlick, Jeff, Sisson, Crystal, Widger, Jenifer, Crocker, Andrea, Vitale, Laura, Marsh, Henry C., Keler, Tibor, He, Li-Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal, Humanized - pharmacology Antitumor activity Blocking antibodies Cancer Research CD27 antigen CD27 Ligand - immunology CD4-Positive T-Lymphocytes - cytology CD70 antigen CD8 antigen CD8-Positive T-Lymphocytes - cytology Cell Line, Tumor Cell Proliferation Cell therapy Chemotherapy Cyclophosphamide Fludarabine Immune System Immunology Immunotherapy Leukopenia Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neoplasms - metabolism Neoplasms - therapy Oncology Original Original Article Signal Transduction T-Lymphocytes - cytology Transgenic mice Transplantation Conditioning Treatment Outcome Tumor Necrosis Factor Receptor Superfamily, Member 7 - chemistry Tumors
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