Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides

Background Pro-apoptotic and pro-inflammatory ceramides are crucially involved in atherosclerotic plaque development. Local cellular ceramide accumulation mediates endothelial apoptosis, especially in type 2 diabetes mellitus, which is a major cardiovascular risk factor. In recent years, large extra...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2022-01, Vol.79 (1), p.48-48, Article 48
Hauptverfasser:	Zietzer, Andreas, Jahnel, Alina Lisann, Bulic, Marko, Gutbrod, Katharina, Düsing, Philip, Hosen, Mohammed Rabiul, Dörmann, Peter, Werner, Nikos, Nickenig, Georg, Jansen, Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arteriosclerosis Atherosclerosis Biochemistry Biomedical and Life Sciences Biomedicine Cardiovascular diseases Carotid Artery Diseases - metabolism Caspase-3 Cell Biology Cell Line Ceramide Ceramides - metabolism Coronary artery Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Endothelial Cells Extracellular vesicles Extracellular Vesicles - metabolism Glucose Health risks Humans Hyperglycemia Inductors Inflammation Injuries Life Sciences Male Mice Mice, Inbred C57BL Original Original Article Risk analysis Risk factors siRNA Spectrometry Sphingomyelin phosphodiesterase Sphingomyelin Phosphodiesterase - physiology Streptozocin
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