Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism

Cells coordinate their behaviors with the mechanical properties of the extracellular matrix (ECM). Tumor cells frequently harbor an enhanced nucleotide synthesis, presumably to meet the increased demands for rapid proliferation. Nevertheless, how ECM rigidity regulates nucleotide metabolism remains...

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Veröffentlicht in:	Cell death and differentiation 2022-01, Vol.29 (1), p.206-217
Hauptverfasser:	Li, Jingyi, Shao, Jichun, Zeng, Zhijun, He, Yumin, Tang, Can, Park, Su Hwan, Lee, Jong-Ho, Liu, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/67/2327 82/51 82/80 Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Extracellular matrix Glycolysis Life Sciences Ligases - metabolism Mechanical properties Metabolism Metastases Nucleotides - metabolism Phosphoribosyl Pyrophosphate Phosphorylation Ribose-Phosphate Pyrophosphokinase - genetics Ribose-Phosphate Pyrophosphokinase - metabolism Stem Cells TRAF2 protein Tumor cells Tumor necrosis factor Tumor necrosis factor receptors Tumor suppressor genes Ubiquitination
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