G protein‐coupled receptor kinases are associated with Alzheimer's disease pathology

Aim Alzheimer's disease (AD) is characterised by extracellular deposition of amyloid‐β (Aβ) in amyloid plaques and intracellular aggregation and accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs). Although several kinases have been identified to contribute to the patholog...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2021-12, Vol.47 (7), p.942-957
Hauptverfasser:	Guimarães, Thais Rafael, Swanson, Eric, Kofler, Julia, Thathiah, Amantha
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism amyloid β Astrocytes Astrocytes - metabolism Autopsy b-Adrenergic-receptor kinase Biochemical analysis Brain - pathology Clinical trials G protein-coupled receptors G protein‐coupled receptor kinase G-Protein-Coupled Receptor Kinases - metabolism hippocampus Humans Kinases Mental disorders Microglia Movement disorders Neurodegenerative diseases neurofibrillary tangle Neurofibrillary tangles Neurofibrillary Tangles - pathology Neurological diseases Neurons - pathology Parkinson's disease Pathology Phosphorylation Schizophrenia Senile plaques Synuclein tau Tau protein tau Proteins - metabolism Tubulin β-Amyloid
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