Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chem...
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| Veröffentlicht in: | General thoracic and cardiovascular surgery 2022-01, Vol.70 (1), p.1-10 |
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| creator | Jiang, Qin Huang, Keli Lu, Fang Deng, Shaoping Yang, Zhenglin Hu, Shengshou |
| description | Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques. |
| doi_str_mv | 10.1007/s11748-021-01696-0 |
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The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.</description><identifier>ISSN: 1863-6705</identifier><identifier>EISSN: 1863-6713</identifier><identifier>DOI: 10.1007/s11748-021-01696-0</identifier><identifier>PMID: 34510332</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Apoptosis ; Cardiac function ; Cardiac Surgery ; Cardiology ; Chemokine CXCL12 ; Chemokines ; Clinical trials ; Extracellular vesicles ; Granulocytes ; Heart ; Hormones ; Humans ; Hypoxia ; Ischemia ; Medicine ; Medicine & Public Health ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Myocardial Infarction ; Myocardial Ischemia ; Peptides ; Proteins ; Receptors, CXCR4 - genetics ; Review ; Review Article ; Stem cell transplantation ; Stem cells ; Surgical Oncology ; Thoracic Surgery ; Ultrasonic imaging</subject><ispartof>General thoracic and cardiovascular surgery, 2022-01, Vol.70 (1), p.1-10</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-aa73152d49dc1cf1721f49d4c3d427c1e2861b94a138f9f59d172b7444985acd3</citedby><cites>FETCH-LOGICAL-c498t-aa73152d49dc1cf1721f49d4c3d427c1e2861b94a138f9f59d172b7444985acd3</cites><orcidid>0000-0002-5821-359X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11748-021-01696-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918741754?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,21367,27901,27902,33721,33722,41464,42533,43781,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34510332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Qin</creatorcontrib><creatorcontrib>Huang, Keli</creatorcontrib><creatorcontrib>Lu, Fang</creatorcontrib><creatorcontrib>Deng, Shaoping</creatorcontrib><creatorcontrib>Yang, Zhenglin</creatorcontrib><creatorcontrib>Hu, Shengshou</creatorcontrib><title>Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation</title><title>General thoracic and cardiovascular surgery</title><addtitle>Gen Thorac Cardiovasc Surg</addtitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><description>Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.</description><subject>Apoptosis</subject><subject>Cardiac function</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Chemokine CXCL12</subject><subject>Chemokines</subject><subject>Clinical trials</subject><subject>Extracellular vesicles</subject><subject>Granulocytes</subject><subject>Heart</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal Stem Cells</subject><subject>Myocardial Infarction</subject><subject>Myocardial Ischemia</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Review</subject><subject>Review Article</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Surgical Oncology</subject><subject>Thoracic Surgery</subject><subject>Ultrasonic imaging</subject><issn>1863-6705</issn><issn>1863-6713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtr3DAUhUVIaB7tH8giGLLJxhldPSx7UyiTTBJIKPQB3RShkeUZDbY0kezA_PvInWSSdtGVLug7R_foIHQK-BIwFpMIIFiZYwI5hqIqcryHjqAsaF4IoPu7GfNDdBzjCmNelMA_oEPKOGBKyRH6_eBr22ysW2SxD6o3C2ti1viQfb-a5TCZ_pp-Y5l1vQlK99a7rB7CSHcmGqeXm061SWm6TJu2zZKFi-tWuV6N8Ed00Kg2mk8v5wn6Obv-Mb3N77_e3E2_3OeaVWWfKyUocFKzqtagGxAEmjQzTWtGhAZDygLmFVNAy6ZqeFUnZC4YS2qudE1P0Oet73qYd6bWxqVFWrkOtlNhI72y8u8bZ5dy4Z9kKSipGE4GFy8GwT8OJvays3FMpJzxQ5SEC0IoTt-a0PN_0JUfgkvxJKmgFAwEZ4kiW0oHH2MwzW4ZwHJsT27bk6k9-ac9OW5x9j7GTvJaVwLoFojrsQQT3t7-j-0zMBClwg</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Jiang, Qin</creator><creator>Huang, Keli</creator><creator>Lu, Fang</creator><creator>Deng, Shaoping</creator><creator>Yang, Zhenglin</creator><creator>Hu, Shengshou</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5821-359X</orcidid></search><sort><creationdate>20220101</creationdate><title>Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation</title><author>Jiang, Qin ; Huang, Keli ; Lu, Fang ; Deng, Shaoping ; Yang, Zhenglin ; Hu, Shengshou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-aa73152d49dc1cf1721f49d4c3d427c1e2861b94a138f9f59d172b7444985acd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>Cardiac function</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Chemokine CXCL12</topic><topic>Chemokines</topic><topic>Clinical trials</topic><topic>Extracellular vesicles</topic><topic>Granulocytes</topic><topic>Heart</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal Stem Cells</topic><topic>Myocardial Infarction</topic><topic>Myocardial Ischemia</topic><topic>Peptides</topic><topic>Proteins</topic><topic>Receptors, CXCR4 - genetics</topic><topic>Review</topic><topic>Review Article</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Surgical Oncology</topic><topic>Thoracic Surgery</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Qin</creatorcontrib><creatorcontrib>Huang, Keli</creatorcontrib><creatorcontrib>Lu, Fang</creatorcontrib><creatorcontrib>Deng, Shaoping</creatorcontrib><creatorcontrib>Yang, Zhenglin</creatorcontrib><creatorcontrib>Hu, Shengshou</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>General thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Qin</au><au>Huang, Keli</au><au>Lu, Fang</au><au>Deng, Shaoping</au><au>Yang, Zhenglin</au><au>Hu, Shengshou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation</atitle><jtitle>General thoracic and cardiovascular surgery</jtitle><stitle>Gen Thorac Cardiovasc Surg</stitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>70</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1863-6705</issn><eissn>1863-6713</eissn><abstract>Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34510332</pmid><doi>10.1007/s11748-021-01696-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5821-359X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Cardiac function Cardiac Surgery Cardiology Chemokine CXCL12 Chemokines Clinical trials Extracellular vesicles Granulocytes Heart Hormones Humans Hypoxia Ischemia Medicine Medicine & Public Health Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells Myocardial Infarction Myocardial Ischemia Peptides Proteins Receptors, CXCR4 - genetics Review Review Article Stem cell transplantation Stem cells Surgical Oncology Thoracic Surgery Ultrasonic imaging |
| title | Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation |
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