Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin

Cadherin-mediated cell adhesion requires anchoring via the β-catenin-α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial cells and strongly stabilizes endothelial junctions in viv...

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Veröffentlicht in:	Journal of cell science 2021-12, Vol.134 (24)
Hauptverfasser:	Duong, Cao Nguyen, Brückner, Randy, Schmitt, Martina, Nottebaum, Astrid F, Braun, Laura J, Meyer Zu Brickwedde, Marika, Ipe, Ute, Vom Bruch, Hermann, Schöler, Hans R, Trapani, Giuseppe, Trappmann, Britta, Ebrahimkutty, Mirsana P, Huveneers, Stephan, de Rooij, Johan, Ishiyama, Noboru, Ikura, Mitsuhiko, Vestweber, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton Actins - genetics Adhesion alpha Catenin - genetics Cadherins - genetics Endothelial Cells Intercellular Junctions Mechanotransduction Vinculin
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