Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans
Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European...
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| Veröffentlicht in: | Leukemia 2022-01, Vol.36 (1), p.119-125 |
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| creator | Kleinstern, Geffen Weinberg, J. Brice Parikh, Sameer A. Braggio, Esteban Achenbach, Sara J. Robinson, Dennis P. Norman, Aaron D. Rabe, Kari G. Boddicker, Nicholas J. Vachon, Celine M. Lesnick, Connie E. Call, Timothy G. Brander, Danielle M. Rassenti, Laura Z. Kipps, Thomas J. Olson, Janet E. Cerhan, James R. Kay, Neil E. Furman, Richard R. Hanson, Curtis A. Shanafelt, Tait D. Slager, Susan L. |
| description | Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86,
P
= 1.9 × 10
−29
, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53,
P
= 4.0 × 10
−63
, c-statistic = 0.77) and AA-CLL risk (OR = 1.76,
P
= 5.1 × 10
−5
, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population. |
| doi_str_mv | 10.1038/s41375-021-01344-9 |
| format | Article |
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P
= 1.9 × 10
−29
, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53,
P
= 4.0 × 10
−63
, c-statistic = 0.77) and AA-CLL risk (OR = 1.76,
P
= 5.1 × 10
−5
, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/s41375-021-01344-9</identifier><identifier>PMID: 34285341</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/43 ; 692/308/174 ; 692/308/2056 ; 692/499 ; Adult ; African Americans ; Aged ; Aged, 80 and over ; B-Lymphocytes - metabolism ; B-Lymphocytes - pathology ; Biobanks ; Biomarkers, Tumor - genetics ; Black or African American - genetics ; Black or African American - statistics & numerical data ; Cancer Research ; Case-Control Studies ; Chronic lymphocytic leukemia ; Clone Cells ; Cloning ; Confidence intervals ; Consortia ; Critical Care Medicine ; Environmental factors ; Epidemiology ; Family medical history ; Female ; Follow-Up Studies ; Genealogy ; Genetic factors ; Hematology ; Humans ; Immunoglobulins - genetics ; Immunoglobulins - immunology ; Immunophenotyping ; Intensive ; Internal Medicine ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Leukemia, Lymphocytic, Chronic, B-Cell - pathology ; Lymphatic leukemia ; Lymphocytes B ; Lymphocytosis ; Lymphocytosis - epidemiology ; Lymphocytosis - genetics ; Lymphocytosis - pathology ; Lymphoma ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minority & ethnic groups ; Oncology ; Population ; Prognosis ; Questionnaires ; Risk ; Risk Factors ; Sex ; Statistical analysis ; United States - epidemiology ; White people ; White People - genetics ; White People - statistics & numerical data ; Working groups</subject><ispartof>Leukemia, 2022-01, Vol.36 (1), p.119-125</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-833dd58a5074a63ee51ad730d80fea1a5f80cec5fce5c63218117df5a99e36783</citedby><cites>FETCH-LOGICAL-c474t-833dd58a5074a63ee51ad730d80fea1a5f80cec5fce5c63218117df5a99e36783</cites><orcidid>0000-0003-4944-7789 ; 0000-0002-3221-7314 ; 0000-0002-5951-5055 ; 0000-0002-1962-9322 ; 0000-0002-5173-4712 ; 0000-0002-0064-4549 ; 0000-0002-7482-178X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41375-021-01344-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41375-021-01344-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34285341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kleinstern, Geffen</creatorcontrib><creatorcontrib>Weinberg, J. Brice</creatorcontrib><creatorcontrib>Parikh, Sameer A.</creatorcontrib><creatorcontrib>Braggio, Esteban</creatorcontrib><creatorcontrib>Achenbach, Sara J.</creatorcontrib><creatorcontrib>Robinson, Dennis P.</creatorcontrib><creatorcontrib>Norman, Aaron D.</creatorcontrib><creatorcontrib>Rabe, Kari G.</creatorcontrib><creatorcontrib>Boddicker, Nicholas J.</creatorcontrib><creatorcontrib>Vachon, Celine M.</creatorcontrib><creatorcontrib>Lesnick, Connie E.</creatorcontrib><creatorcontrib>Call, Timothy G.</creatorcontrib><creatorcontrib>Brander, Danielle M.</creatorcontrib><creatorcontrib>Rassenti, Laura Z.</creatorcontrib><creatorcontrib>Kipps, Thomas J.</creatorcontrib><creatorcontrib>Olson, Janet E.</creatorcontrib><creatorcontrib>Cerhan, James R.</creatorcontrib><creatorcontrib>Kay, Neil E.</creatorcontrib><creatorcontrib>Furman, Richard R.</creatorcontrib><creatorcontrib>Hanson, Curtis A.</creatorcontrib><creatorcontrib>Shanafelt, Tait D.</creatorcontrib><creatorcontrib>Slager, Susan L.</creatorcontrib><title>Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><description>Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86,
P
= 1.9 × 10
−29
, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53,
P
= 4.0 × 10
−63
, c-statistic = 0.77) and AA-CLL risk (OR = 1.76,
P
= 5.1 × 10
−5
, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.</description><subject>45</subject><subject>45/43</subject><subject>692/308/174</subject><subject>692/308/2056</subject><subject>692/499</subject><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-Lymphocytes - metabolism</subject><subject>B-Lymphocytes - pathology</subject><subject>Biobanks</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Black or African American - genetics</subject><subject>Black or African American - statistics & numerical data</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Chronic lymphocytic leukemia</subject><subject>Clone Cells</subject><subject>Cloning</subject><subject>Confidence intervals</subject><subject>Consortia</subject><subject>Critical Care Medicine</subject><subject>Environmental factors</subject><subject>Epidemiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genealogy</subject><subject>Genetic factors</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunoglobulins - genetics</subject><subject>Immunoglobulins - immunology</subject><subject>Immunophenotyping</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</subject><subject>Lymphatic leukemia</subject><subject>Lymphocytes B</subject><subject>Lymphocytosis</subject><subject>Lymphocytosis - epidemiology</subject><subject>Lymphocytosis - genetics</subject><subject>Lymphocytosis - pathology</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Oncology</subject><subject>Population</subject><subject>Prognosis</subject><subject>Questionnaires</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Sex</subject><subject>Statistical analysis</subject><subject>United States - epidemiology</subject><subject>White people</subject><subject>White People - genetics</subject><subject>White People - statistics & numerical data</subject><subject>Working groups</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UUtv1DAQtioQXQp_oIfKEhd6MPgZO5dKZVUe0kr0UM6WcSa7bhN7a2-Q9m_wi0masqUXTjOj7zGj-RA6ZfQDo8J8LJIJrQjljFAmpCT1EVowqSuilGIv0IIao0lVc3mMXpdyS-kEVq_QsZDcKCHZAv2-Tt1-DTF4nEO5w8WnDNjFZh5Ti_sUk-9SdB3-RDx0He72_XaT_H6XSig4ROzd4F0JLpZnSr_JaTI-8Kcehjvog8Pvl6vV-SS-bHPwbqw9PDTlDXrZuq7A28d6gn58vrpZfiWr71--LS9XxEstd8QI0TTKOEW1dJUAUMw1WtDG0BYcc6o11INXrQflK8GZYUw3rXJ1DaLSRpygi9l3O_zsofEQd9l1dptD7_LeJhfscySGjV2nX9ZorrmZDN49GuR0P0DZ2ds05PFRxfKKVVIrqfnI4jPL51RKhvawgVE75WjnHO2Yo33I0daj6Ozf2w6Sv8GNBDETygjFNeSn3f-x_QPqBKvu</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Kleinstern, Geffen</creator><creator>Weinberg, J. 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Brice ; Parikh, Sameer A. ; Braggio, Esteban ; Achenbach, Sara J. ; Robinson, Dennis P. ; Norman, Aaron D. ; Rabe, Kari G. ; Boddicker, Nicholas J. ; Vachon, Celine M. ; Lesnick, Connie E. ; Call, Timothy G. ; Brander, Danielle M. ; Rassenti, Laura Z. ; Kipps, Thomas J. ; Olson, Janet E. ; Cerhan, James R. ; Kay, Neil E. ; Furman, Richard R. ; Hanson, Curtis A. ; Shanafelt, Tait D. ; Slager, Susan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-833dd58a5074a63ee51ad730d80fea1a5f80cec5fce5c63218117df5a99e36783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>45</topic><topic>45/43</topic><topic>692/308/174</topic><topic>692/308/2056</topic><topic>692/499</topic><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B-Lymphocytes - metabolism</topic><topic>B-Lymphocytes - pathology</topic><topic>Biobanks</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Black or African American - genetics</topic><topic>Black or African American - statistics & numerical data</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Chronic lymphocytic leukemia</topic><topic>Clone Cells</topic><topic>Cloning</topic><topic>Confidence intervals</topic><topic>Consortia</topic><topic>Critical Care Medicine</topic><topic>Environmental factors</topic><topic>Epidemiology</topic><topic>Family medical history</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genealogy</topic><topic>Genetic factors</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulins - genetics</topic><topic>Immunoglobulins - immunology</topic><topic>Immunophenotyping</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Leukemia</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - pathology</topic><topic>Lymphatic leukemia</topic><topic>Lymphocytes B</topic><topic>Lymphocytosis</topic><topic>Lymphocytosis - epidemiology</topic><topic>Lymphocytosis - genetics</topic><topic>Lymphocytosis - pathology</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Oncology</topic><topic>Population</topic><topic>Prognosis</topic><topic>Questionnaires</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Sex</topic><topic>Statistical analysis</topic><topic>United States - epidemiology</topic><topic>White people</topic><topic>White People - genetics</topic><topic>White People - statistics & numerical data</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kleinstern, Geffen</creatorcontrib><creatorcontrib>Weinberg, J. Brice</creatorcontrib><creatorcontrib>Parikh, Sameer A.</creatorcontrib><creatorcontrib>Braggio, Esteban</creatorcontrib><creatorcontrib>Achenbach, Sara J.</creatorcontrib><creatorcontrib>Robinson, Dennis P.</creatorcontrib><creatorcontrib>Norman, Aaron D.</creatorcontrib><creatorcontrib>Rabe, Kari G.</creatorcontrib><creatorcontrib>Boddicker, Nicholas J.</creatorcontrib><creatorcontrib>Vachon, Celine M.</creatorcontrib><creatorcontrib>Lesnick, Connie E.</creatorcontrib><creatorcontrib>Call, Timothy G.</creatorcontrib><creatorcontrib>Brander, Danielle M.</creatorcontrib><creatorcontrib>Rassenti, Laura Z.</creatorcontrib><creatorcontrib>Kipps, Thomas J.</creatorcontrib><creatorcontrib>Olson, Janet E.</creatorcontrib><creatorcontrib>Cerhan, James R.</creatorcontrib><creatorcontrib>Kay, Neil E.</creatorcontrib><creatorcontrib>Furman, Richard R.</creatorcontrib><creatorcontrib>Hanson, Curtis A.</creatorcontrib><creatorcontrib>Shanafelt, Tait D.</creatorcontrib><creatorcontrib>Slager, Susan L.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kleinstern, Geffen</au><au>Weinberg, J. Brice</au><au>Parikh, Sameer A.</au><au>Braggio, Esteban</au><au>Achenbach, Sara J.</au><au>Robinson, Dennis P.</au><au>Norman, Aaron D.</au><au>Rabe, Kari G.</au><au>Boddicker, Nicholas J.</au><au>Vachon, Celine M.</au><au>Lesnick, Connie E.</au><au>Call, Timothy G.</au><au>Brander, Danielle M.</au><au>Rassenti, Laura Z.</au><au>Kipps, Thomas J.</au><au>Olson, Janet E.</au><au>Cerhan, James R.</au><au>Kay, Neil E.</au><au>Furman, Richard R.</au><au>Hanson, Curtis A.</au><au>Shanafelt, Tait D.</au><au>Slager, Susan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>36</volume><issue>1</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>Monoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86,
P
= 1.9 × 10
−29
, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53,
P
= 4.0 × 10
−63
, c-statistic = 0.77) and AA-CLL risk (OR = 1.76,
P
= 5.1 × 10
−5
, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34285341</pmid><doi>10.1038/s41375-021-01344-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4944-7789</orcidid><orcidid>https://orcid.org/0000-0002-3221-7314</orcidid><orcidid>https://orcid.org/0000-0002-5951-5055</orcidid><orcidid>https://orcid.org/0000-0002-1962-9322</orcidid><orcidid>https://orcid.org/0000-0002-5173-4712</orcidid><orcidid>https://orcid.org/0000-0002-0064-4549</orcidid><orcidid>https://orcid.org/0000-0002-7482-178X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2022-01, Vol.36 (1), p.119-125 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8727288 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 45 45/43 692/308/174 692/308/2056 692/499 Adult African Americans Aged Aged, 80 and over B-Lymphocytes - metabolism B-Lymphocytes - pathology Biobanks Biomarkers, Tumor - genetics Black or African American - genetics Black or African American - statistics & numerical data Cancer Research Case-Control Studies Chronic lymphocytic leukemia Clone Cells Cloning Confidence intervals Consortia Critical Care Medicine Environmental factors Epidemiology Family medical history Female Follow-Up Studies Genealogy Genetic factors Hematology Humans Immunoglobulins - genetics Immunoglobulins - immunology Immunophenotyping Intensive Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Lymphocytes B Lymphocytosis Lymphocytosis - epidemiology Lymphocytosis - genetics Lymphocytosis - pathology Lymphoma Male Medicine Medicine & Public Health Middle Aged Minority & ethnic groups Oncology Population Prognosis Questionnaires Risk Risk Factors Sex Statistical analysis United States - epidemiology White people White People - genetics White People - statistics & numerical data Working groups |
| title | Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T08%3A48%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polygenic%20risk%20score%20and%20risk%20of%20monoclonal%20B-cell%20lymphocytosis%20in%20caucasians%20and%20risk%20of%20chronic%20lymphocytic%20leukemia%20(CLL)%20in%20African%20Americans&rft.jtitle=Leukemia&rft.au=Kleinstern,%20Geffen&rft.date=2022-01-01&rft.volume=36&rft.issue=1&rft.spage=119&rft.epage=125&rft.pages=119-125&rft.issn=0887-6924&rft.eissn=1476-5551&rft_id=info:doi/10.1038/s41375-021-01344-9&rft_dat=%3Cproquest_pubme%3E2616475472%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2616475472&rft_id=info:pmid/34285341&rfr_iscdi=true |