Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats

Exchanges of protein sequence modules support leaps in function unavailable through point mutations during evolution. Here we study the role of the two RAD51-interacting modules within the eight binding BRC repeats of BRCA2. We created 64 chimeric repeats by shuffling these modules and measured thei...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-11, Vol.118 (46), p.1-11
Hauptverfasser:	Lindenburg, Laurens H., Pantelejevs, Teodors, Gielen, Fabrice, Zuazua-Villar, Pedro, Butz, Maren, Rees, Eric, Kaminski, Clemens F., Downs, Jessica A., Hyvönen, Marko, Hollfelder, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binders Binding Biological Sciences BRCA2 protein BRCA2 Protein - metabolism Breast cancer Cell Line, Tumor Chimeras Crystal structure Humans Ionizing radiation Modularity Modules Mutation Protein Binding - physiology Rad51 Recombinase - metabolism
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