Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We previously showed that heat shock protein 27 (HSP27) acted as a driver of castration-resistant phenotype (CRPC) and developed an oligonucleotides an...

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Veröffentlicht in:	Oncogene 2022-01, Vol.41 (1), p.125-137
Hauptverfasser:	Cherif, Chaïma, Nguyen, Dang Tan, Paris, Clément, Le, Thi Khanh, Sefiane, Thibaud, Carbuccia, Nadine, Finetti, Pascal, Chaffanet, Max, kaoutari, Abdessamad El, Vernerey, Julien, Fazli, Ladan, Gleave, Martin, Manai, Mohamed, Barthélémy, Philippe, Birnbaum, Daniel, Bertucci, François, Taïeb, David, Rocchi, Palma
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/2 13/31 13/51 14/19 38 38/23 631/67/68 631/80/86/2363 64/60 82/29 82/51 82/58 Animals Antisense oligonucleotides Antitumor activity Apoptosis Binding sites Castration Cell Biology Cell Line, Tumor Cell Proliferation Disease resistance Gene expression Genomics Genomics - methods Heat shock proteins Hsp27 protein Human Genetics Humans Internal Medicine Life Sciences Male Medicine Medicine & Public Health Oligonucleotides Oncology Phenotypes Prostate cancer Prostatic Neoplasms, Castration-Resistant Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology Proto-Oncogene Proteins Proto-Oncogene Proteins - metabolism Tumor suppressor genes Tumors
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