Combined control of the fibroblast contractile program by YAP and TAZ

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcription cofactors implicated in the contractile and profibrotic activation of fibroblasts. Fibroblast contractile function is important in alveologenesis and in lung wound healing and fibrosis. As par...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2022-01, Vol.322 (1), p.L23-L32
Hauptverfasser:	Link, Patrick A, Choi, Kyoung Moo, Diaz Espinosa, Ana M, Jones, Dakota L, Gao, Ashley Y, Haak, Andrew J, Tschumperlin, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomechanical Phenomena - drug effects Cell Line Cofactors Contractility Cytoskeleton DNA microarrays Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Gene expression Gene Expression Regulation - drug effects Genes Growth factors Humans Lung diseases Lungs Redundancy RNA, Messenger - genetics RNA, Messenger - metabolism Transcription activation Transcriptional Coactivator with PDZ-Binding Motif Proteins - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Wound healing YAP-Signaling Proteins - metabolism Yes-associated protein
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