Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair
Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are re...
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| Veröffentlicht in: | Journal of biomaterials applications 2022-01, Vol.36 (6), p.996-1010 |
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| creator | Smith, Matthew J Dempsey, Sandi G Veale, Robert WF Duston-Fursman, Claudia G Rayner, Chloe A F Javanapong, Chettha Gerneke, Dane Dowling, Shane G Bosque, Brandon A Karnik, Tanvi Jerram, Michael J Nagarajan, Arun Rajam, Ravinder Jowsey, Alister Cutajar, Samuel Mason, Isaac Stanley, Roderick G Campbell, Andrew Malmstrom, Jenny Miller, Chris H May, Barnaby C H |
| description | Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties. |
| doi_str_mv | 10.1177/08853282211045770 |
| format | Article |
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Multi-layered dECM devices have been developed for clinical indications where additional thickness and biomechanical performance are required. However, traditional approaches to the fabrication of multi-layered dECM devices introduce additional laminating materials or chemical modifications of the dECM that may impair the biological functionality of the material. Using an established dECM biomaterial, ovine forestomach matrix, a novel method for the fabrication of multi-layered dECM constructs has been developed, where layers are bonded via a physical interlocking process without the need for additional bonding materials or detrimental chemical modification of the dECM. The versatility of the interlocking process has been demonstrated by incorporating a layer of hyaluronic acid to create a composite material with additional biological functionality. Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties.</description><identifier>ISSN: 0885-3282</identifier><identifier>EISSN: 1530-8022</identifier><identifier>DOI: 10.1177/08853282211045770</identifier><identifier>PMID: 34747247</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Biocompatible Materials - chemistry ; Biomaterials Processing ; Extracellular Matrix - chemistry ; Sheep ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of biomaterials applications, 2022-01, Vol.36 (6), p.996-1010</ispartof><rights>Aroa Biosurgery Limited</rights><rights>Aroa Biosurgery Limited 2021 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f7feefaca410a0f9d20d738bc3413a6c060b86da84a9c9a371f9f016e015881f3</citedby><cites>FETCH-LOGICAL-c438t-f7feefaca410a0f9d20d738bc3413a6c060b86da84a9c9a371f9f016e015881f3</cites><orcidid>0000-0001-9855-018X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/08853282211045770$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/08853282211045770$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34747247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Matthew J</creatorcontrib><creatorcontrib>Dempsey, Sandi G</creatorcontrib><creatorcontrib>Veale, Robert WF</creatorcontrib><creatorcontrib>Duston-Fursman, Claudia G</creatorcontrib><creatorcontrib>Rayner, Chloe A F</creatorcontrib><creatorcontrib>Javanapong, Chettha</creatorcontrib><creatorcontrib>Gerneke, Dane</creatorcontrib><creatorcontrib>Dowling, Shane G</creatorcontrib><creatorcontrib>Bosque, Brandon A</creatorcontrib><creatorcontrib>Karnik, Tanvi</creatorcontrib><creatorcontrib>Jerram, Michael J</creatorcontrib><creatorcontrib>Nagarajan, Arun</creatorcontrib><creatorcontrib>Rajam, Ravinder</creatorcontrib><creatorcontrib>Jowsey, Alister</creatorcontrib><creatorcontrib>Cutajar, Samuel</creatorcontrib><creatorcontrib>Mason, Isaac</creatorcontrib><creatorcontrib>Stanley, Roderick G</creatorcontrib><creatorcontrib>Campbell, Andrew</creatorcontrib><creatorcontrib>Malmstrom, Jenny</creatorcontrib><creatorcontrib>Miller, Chris H</creatorcontrib><creatorcontrib>May, Barnaby C H</creatorcontrib><title>Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair</title><title>Journal of biomaterials applications</title><addtitle>J Biomater Appl</addtitle><description>Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. 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Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties.</description><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biomaterials Processing</subject><subject>Extracellular Matrix - chemistry</subject><subject>Sheep</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0885-3282</issn><issn>1530-8022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhi0EooeWB2CDvGST4ltiZ4OEKgpIlbqha2uOM-5xlcQHX6qWJ-CxSXTaCoTU1Szm-_-5_IS84-yUc60_MmNaKYwQnDPVas1ekA1vJWsME-Il2az9ZgWOyJucbxhjba-61-RIKq20UHpDfp_XVHaYaC6pulITjNTtIIErmMIvKCHONHoab8OM1MeEucQJ3I5OUFK4ozAPdKpjCc0I95hwoHhXFjmOYx0hPWIuTvuYQ8G8mtAcfaEl5FyRJtxDSCfklYcx49uHekyuzr_8OPvWXFx-_X72-aJxSprSeO0RPThQnAHz_SDYoKXZOqm4hM6xjm1NN4BR0LsepOa-94x3yHhrDPfymHw6-O7rdsLB4bxsO9p9ChOkexsh2H87c9jZ63hrjRa8M3ox-PBgkOLPurzDTiGv58KMsWYr2r7lQnK5ovyAuhRzTuifxnBm1wTtfwkumvd_7_ekeIxsAU4PQIZrtDexpnn51zOOfwCjfKlN</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Smith, Matthew J</creator><creator>Dempsey, Sandi G</creator><creator>Veale, Robert WF</creator><creator>Duston-Fursman, Claudia G</creator><creator>Rayner, Chloe A F</creator><creator>Javanapong, Chettha</creator><creator>Gerneke, Dane</creator><creator>Dowling, Shane G</creator><creator>Bosque, Brandon A</creator><creator>Karnik, Tanvi</creator><creator>Jerram, Michael J</creator><creator>Nagarajan, Arun</creator><creator>Rajam, Ravinder</creator><creator>Jowsey, Alister</creator><creator>Cutajar, Samuel</creator><creator>Mason, Isaac</creator><creator>Stanley, Roderick G</creator><creator>Campbell, Andrew</creator><creator>Malmstrom, Jenny</creator><creator>Miller, Chris H</creator><creator>May, Barnaby C H</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9855-018X</orcidid></search><sort><creationdate>20220101</creationdate><title>Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair</title><author>Smith, Matthew J ; Dempsey, Sandi G ; Veale, Robert WF ; Duston-Fursman, Claudia G ; Rayner, Chloe A F ; Javanapong, Chettha ; Gerneke, Dane ; Dowling, Shane G ; Bosque, Brandon A ; Karnik, Tanvi ; Jerram, Michael J ; Nagarajan, Arun ; Rajam, Ravinder ; Jowsey, Alister ; Cutajar, Samuel ; Mason, Isaac ; Stanley, Roderick G ; Campbell, Andrew ; Malmstrom, Jenny ; Miller, Chris H ; May, Barnaby C H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f7feefaca410a0f9d20d738bc3413a6c060b86da84a9c9a371f9f016e015881f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biomaterials Processing</topic><topic>Extracellular Matrix - chemistry</topic><topic>Sheep</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Matthew J</creatorcontrib><creatorcontrib>Dempsey, Sandi G</creatorcontrib><creatorcontrib>Veale, Robert WF</creatorcontrib><creatorcontrib>Duston-Fursman, Claudia G</creatorcontrib><creatorcontrib>Rayner, Chloe A F</creatorcontrib><creatorcontrib>Javanapong, Chettha</creatorcontrib><creatorcontrib>Gerneke, Dane</creatorcontrib><creatorcontrib>Dowling, Shane G</creatorcontrib><creatorcontrib>Bosque, Brandon A</creatorcontrib><creatorcontrib>Karnik, Tanvi</creatorcontrib><creatorcontrib>Jerram, Michael J</creatorcontrib><creatorcontrib>Nagarajan, Arun</creatorcontrib><creatorcontrib>Rajam, Ravinder</creatorcontrib><creatorcontrib>Jowsey, Alister</creatorcontrib><creatorcontrib>Cutajar, Samuel</creatorcontrib><creatorcontrib>Mason, Isaac</creatorcontrib><creatorcontrib>Stanley, Roderick G</creatorcontrib><creatorcontrib>Campbell, Andrew</creatorcontrib><creatorcontrib>Malmstrom, Jenny</creatorcontrib><creatorcontrib>Miller, Chris H</creatorcontrib><creatorcontrib>May, Barnaby C H</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomaterials applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Matthew J</au><au>Dempsey, Sandi G</au><au>Veale, Robert WF</au><au>Duston-Fursman, Claudia G</au><au>Rayner, Chloe A F</au><au>Javanapong, Chettha</au><au>Gerneke, Dane</au><au>Dowling, Shane G</au><au>Bosque, Brandon A</au><au>Karnik, Tanvi</au><au>Jerram, Michael J</au><au>Nagarajan, Arun</au><au>Rajam, Ravinder</au><au>Jowsey, Alister</au><au>Cutajar, Samuel</au><au>Mason, Isaac</au><au>Stanley, Roderick G</au><au>Campbell, Andrew</au><au>Malmstrom, Jenny</au><au>Miller, Chris H</au><au>May, Barnaby C H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair</atitle><jtitle>Journal of biomaterials applications</jtitle><addtitle>J Biomater Appl</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>36</volume><issue>6</issue><spage>996</spage><epage>1010</epage><pages>996-1010</pages><issn>0885-3282</issn><eissn>1530-8022</eissn><abstract>Decellularized extracellular matrix (dECM)–based biomaterials are of great clinical utility in soft tissue repair applications due to their regenerative properties. 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Interlocked composite devices including hyaluronic acid showed improved in vitro bioactivity and moisture retention properties.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>34747247</pmid><doi>10.1177/08853282211045770</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-9855-018X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0885-3282 |
| ispartof | Journal of biomaterials applications, 2022-01, Vol.36 (6), p.996-1010 |
| issn | 0885-3282 1530-8022 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Animals Biocompatible Materials - chemistry Biomaterials Processing Extracellular Matrix - chemistry Sheep Tissue Engineering - methods Tissue Scaffolds - chemistry |
| title | Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair |
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