Resolving the immune landscape of human prostate at a single-cell level in health and cancer

The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment efficacy in castration-resistant metastatic disease, including with immune checkpoint inhibitors. Using single-cell RNA...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-12, Vol.37 (12), p.110132-110132, Article 110132
Hauptverfasser:	Tuong, Zewen Kelvin, Loudon, Kevin W., Berry, Brendan, Richoz, Nathan, Jones, Julia, Tan, Xiao, Nguyen, Quan, George, Anne, Hori, Satoshi, Field, Sarah, Lynch, Andy G., Kania, Katarzyna, Coupland, Paul, Babbage, Anne, Grenfell, Richard, Barrett, Tristan, Warren, Anne Y., Gnanapragasam, Vincent, Massie, Charlie, Clatworthy, Menna R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Epithelial Cells - immunology Epithelial Cells - metabolism Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic human prostate Humans immune landscape macrophage Macrophages - immunology Macrophages - metabolism Male Mice Mice, Inbred C57BL Middle Aged Prostate - immunology Prostate - metabolism prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - metabolism Receptors, Androgen - metabolism Resource RNA-Seq Single-Cell Analysis - methods single-cell RNA sequencing Transcriptome zinc Zinc - metabolism
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