Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2
Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to prolonged CR. Utilizing data from the two-y...
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| Veröffentlicht in: | Experimental gerontology 2021-11, Vol.155, p.111555-111555, Article 111555 |
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| creator | Dorling, James L. Belsky, Daniel W. Racette, Susan B. Das, Sai Krupa Ravussin, Eric Redman, Leanne M. Höchsmann, Christoph Huffman, Kim M. Kraus, William E. Kobor, Michael S. MacIsaac, Julia L. Lin, David T.S. Corcoran, David L. Martin, Corby K. |
| description | Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to prolonged CR. Utilizing data from the two-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 randomized controlled trial, we tested whether the FTO rs9939609 SNP was associated with adherence to CR in healthy adults without obesity. As secondary aims, we assessed whether the FTO rs9939609 SNP was associated with changes in body composition, biomarkers of aging, and eating behaviors. Participants were randomized into either a CR group that targeted a 25% reduction in energy intake compared to the habitual energy intake at baseline, or an ad libitum (AL) control group. Participants were genotyped for the FTO rs9939609 SNP. Dietary adherence was determined through changes in energy intake using doubly labeled water and changes in body composition at baseline, month 12, and month 24 in both the CR and AL condition. Weight, body composition, resting metabolic rate (RMR), adiponectin, insulin, leptin, and eating behaviors were measured at the same timepoints. A total of 144 participants (91 CR and 53 AL, age: 38.6 ± 7.1 years; body mass index: 25.3 ± 1.7 kg/m2) were studied. Of these, 27 were homozygous for the ‘obesity-risk’ A allele (AA), while 44 were homozygous for the T allele (TT) and 73 were heterozygotes (AT). By design, the CR group exhibited greater percent CR compared to the AL group during the trial (P |
| doi_str_mv | 10.1016/j.exger.2021.111555 |
| format | Article |
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Utilizing data from the two-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 randomized controlled trial, we tested whether the FTO rs9939609 SNP was associated with adherence to CR in healthy adults without obesity. As secondary aims, we assessed whether the FTO rs9939609 SNP was associated with changes in body composition, biomarkers of aging, and eating behaviors. Participants were randomized into either a CR group that targeted a 25% reduction in energy intake compared to the habitual energy intake at baseline, or an ad libitum (AL) control group. Participants were genotyped for the FTO rs9939609 SNP. Dietary adherence was determined through changes in energy intake using doubly labeled water and changes in body composition at baseline, month 12, and month 24 in both the CR and AL condition. Weight, body composition, resting metabolic rate (RMR), adiponectin, insulin, leptin, and eating behaviors were measured at the same timepoints. A total of 144 participants (91 CR and 53 AL, age: 38.6 ± 7.1 years; body mass index: 25.3 ± 1.7 kg/m2) were studied. Of these, 27 were homozygous for the ‘obesity-risk’ A allele (AA), while 44 were homozygous for the T allele (TT) and 73 were heterozygotes (AT). By design, the CR group exhibited greater percent CR compared to the AL group during the trial (P < 0.01), but no genotype-by-treatment interaction was observed for change in energy intake or percent CR (P ≥ 0.40). The FTO rs9939609 SNP was also negligibly associated with change in most other endpoints (P ≥ 0.13), though AAs showed a reduction in RMR adjusted for body composition change over the 24 months relative to TTs (genotype-by-treatment interaction: P = 0.03). In a two-year CR intervention delivered to healthy individuals without obesity, the FTO rs9939609 SNP was not associated with adherence to CR and did not alter improvements in most aging biomarkers.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2021.111555</identifier><identifier>PMID: 34543722</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aging ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics ; Body Mass Index ; Caloric Restriction ; Eating behaviors ; Energy Intake ; Fat mass and obesity-associated gene ; Genetic Predisposition to Disease ; Genotype ; Humans ; Longevity ; Metabolic adaptation ; Personalized nutrition ; Polymorphism, Single Nucleotide</subject><ispartof>Experimental gerontology, 2021-11, Vol.155, p.111555-111555, Article 111555</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3745-b5d981dac328c7eae3f69599b3e9203d8da371904404e358e568b221364ee5713</citedby><cites>FETCH-LOGICAL-c3745-b5d981dac328c7eae3f69599b3e9203d8da371904404e358e568b221364ee5713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0531556521003375$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34543722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorling, James L.</creatorcontrib><creatorcontrib>Belsky, Daniel W.</creatorcontrib><creatorcontrib>Racette, Susan B.</creatorcontrib><creatorcontrib>Das, Sai Krupa</creatorcontrib><creatorcontrib>Ravussin, Eric</creatorcontrib><creatorcontrib>Redman, Leanne M.</creatorcontrib><creatorcontrib>Höchsmann, Christoph</creatorcontrib><creatorcontrib>Huffman, Kim M.</creatorcontrib><creatorcontrib>Kraus, William E.</creatorcontrib><creatorcontrib>Kobor, Michael S.</creatorcontrib><creatorcontrib>MacIsaac, Julia L.</creatorcontrib><creatorcontrib>Lin, David T.S.</creatorcontrib><creatorcontrib>Corcoran, David L.</creatorcontrib><creatorcontrib>Martin, Corby K.</creatorcontrib><title>Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to prolonged CR. Utilizing data from the two-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 randomized controlled trial, we tested whether the FTO rs9939609 SNP was associated with adherence to CR in healthy adults without obesity. As secondary aims, we assessed whether the FTO rs9939609 SNP was associated with changes in body composition, biomarkers of aging, and eating behaviors. Participants were randomized into either a CR group that targeted a 25% reduction in energy intake compared to the habitual energy intake at baseline, or an ad libitum (AL) control group. Participants were genotyped for the FTO rs9939609 SNP. Dietary adherence was determined through changes in energy intake using doubly labeled water and changes in body composition at baseline, month 12, and month 24 in both the CR and AL condition. Weight, body composition, resting metabolic rate (RMR), adiponectin, insulin, leptin, and eating behaviors were measured at the same timepoints. A total of 144 participants (91 CR and 53 AL, age: 38.6 ± 7.1 years; body mass index: 25.3 ± 1.7 kg/m2) were studied. Of these, 27 were homozygous for the ‘obesity-risk’ A allele (AA), while 44 were homozygous for the T allele (TT) and 73 were heterozygotes (AT). By design, the CR group exhibited greater percent CR compared to the AL group during the trial (P < 0.01), but no genotype-by-treatment interaction was observed for change in energy intake or percent CR (P ≥ 0.40). The FTO rs9939609 SNP was also negligibly associated with change in most other endpoints (P ≥ 0.13), though AAs showed a reduction in RMR adjusted for body composition change over the 24 months relative to TTs (genotype-by-treatment interaction: P = 0.03). In a two-year CR intervention delivered to healthy individuals without obesity, the FTO rs9939609 SNP was not associated with adherence to CR and did not alter improvements in most aging biomarkers.</description><subject>Aging</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics</subject><subject>Body Mass Index</subject><subject>Caloric Restriction</subject><subject>Eating behaviors</subject><subject>Energy Intake</subject><subject>Fat mass and obesity-associated gene</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Longevity</subject><subject>Metabolic adaptation</subject><subject>Personalized nutrition</subject><subject>Polymorphism, Single Nucleotide</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEokPhCZCQl2wy-Cd2YiSQqmoKlSpVQmVtOfadGY8SO9jJtLPnSXgLXocnwemUCjasrix_59yfUxSvCV4STMS73RLuNhCXFFOyJIRwzp8UC9LUrBQN4U-LBeaMlJwLflK8SGmHMRaUkefFCat4xWpKF8XPs5SCcXp0waMWxlsAj8YtoIubaxSTlEwKLFFyftMB8pPpIIzOAhpCd-hDHLYu9Uh7i6yDUccD0nYLEbwBZKeYZUgjWh5AR2R0F6IzKEIac71v6fwIcQ9-frxHq7shI3oMs4_X3SFBQusYenR-drX6crn69f0HGrY6AaIvi2dr3SV49VBPi68Xq5vzz-XV9afLjJeG1RUvW25lQ6w2jDamBg1sLSSXsmUgKWa2sZrVROKqwhUw3gAXTUspYaIC4DVhp8XHo-8wtT1Yk2eNulNDdH1eVwXt1L8_3m3VJuxVU1PcCJ4N3j4YxPBtyrur3iUDXac9hCkpymuORcMqkVF2RE0MKUVYP7YhWM2hq526D13Noatj6Fn15u8JHzV_Us7AhyMA-U57l-XJuDki6yKYUdng_tvgN7I7wsc</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Dorling, James L.</creator><creator>Belsky, Daniel W.</creator><creator>Racette, Susan B.</creator><creator>Das, Sai Krupa</creator><creator>Ravussin, Eric</creator><creator>Redman, Leanne M.</creator><creator>Höchsmann, Christoph</creator><creator>Huffman, Kim M.</creator><creator>Kraus, William E.</creator><creator>Kobor, Michael S.</creator><creator>MacIsaac, Julia L.</creator><creator>Lin, David T.S.</creator><creator>Corcoran, David L.</creator><creator>Martin, Corby K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211101</creationdate><title>Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2</title><author>Dorling, James L. ; 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but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to prolonged CR. Utilizing data from the two-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 randomized controlled trial, we tested whether the FTO rs9939609 SNP was associated with adherence to CR in healthy adults without obesity. As secondary aims, we assessed whether the FTO rs9939609 SNP was associated with changes in body composition, biomarkers of aging, and eating behaviors. Participants were randomized into either a CR group that targeted a 25% reduction in energy intake compared to the habitual energy intake at baseline, or an ad libitum (AL) control group. Participants were genotyped for the FTO rs9939609 SNP. Dietary adherence was determined through changes in energy intake using doubly labeled water and changes in body composition at baseline, month 12, and month 24 in both the CR and AL condition. Weight, body composition, resting metabolic rate (RMR), adiponectin, insulin, leptin, and eating behaviors were measured at the same timepoints. A total of 144 participants (91 CR and 53 AL, age: 38.6 ± 7.1 years; body mass index: 25.3 ± 1.7 kg/m2) were studied. Of these, 27 were homozygous for the ‘obesity-risk’ A allele (AA), while 44 were homozygous for the T allele (TT) and 73 were heterozygotes (AT). By design, the CR group exhibited greater percent CR compared to the AL group during the trial (P < 0.01), but no genotype-by-treatment interaction was observed for change in energy intake or percent CR (P ≥ 0.40). The FTO rs9939609 SNP was also negligibly associated with change in most other endpoints (P ≥ 0.13), though AAs showed a reduction in RMR adjusted for body composition change over the 24 months relative to TTs (genotype-by-treatment interaction: P = 0.03). In a two-year CR intervention delivered to healthy individuals without obesity, the FTO rs9939609 SNP was not associated with adherence to CR and did not alter improvements in most aging biomarkers.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>34543722</pmid><doi>10.1016/j.exger.2021.111555</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Body Mass Index Caloric Restriction Eating behaviors Energy Intake Fat mass and obesity-associated gene Genetic Predisposition to Disease Genotype Humans Longevity Metabolic adaptation Personalized nutrition Polymorphism, Single Nucleotide |
| title | Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2 |
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