Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

Aggregation and cytoplasmic mislocalization of TDP-43 are pathological hallmarks of amyotrophic lateral sclerosis and frontotemporal dementia spectrum. However, the molecular mechanism by which TDP-43 aggregates form and cause neurodegeneration remains poorly understood. Cyclophilin A, also known as...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2021-12, Vol.144 (12), p.3710-3726
Hauptverfasser:	Pasetto, Laura, Grassano, Maurizio, Pozzi, Silvia, Luotti, Silvia, Sammali, Eliana, Migazzi, Alice, Basso, Manuela, Spagnolli, Giovanni, Biasini, Emiliano, Micotti, Edoardo, Cerovic, Milica, Carli, Mirjana, Forloni, Gianluigi, De Marco, Giovanni, Manera, Umberto, Moglia, Cristina, Mora, Gabriele, Traynor, Bryan J, Chiò, Adriano, Calvo, Andrea, Bonetto, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - pathology Animals Cyclophilin A - deficiency Cyclophilin A - genetics DNA-Binding Proteins - metabolism Editor's Choice Frontotemporal Dementia - genetics Frontotemporal Dementia - pathology Humans Mice Mice, Knockout Original
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