SIRT5 Directly Inhibits the PI3K/AKT Pathway in Prostate Cancer Cell Lines

Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men globally. Among patients who develop advanced PCa, 80% are affected by bone metastasis, with a sharp drop in survival rate. Despite efforts, the details of mechanisms of metastasis of PCa remain unclear. SIRT5, an NAD -depend...

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Veröffentlicht in:	Cancer genomics & proteomics 2022-01, Vol.19 (1), p.50-59
Hauptverfasser:	Choi, So Young, Jeon, Ju Mi, Na, Ann Yae, Kwon, Oh Kwang, Bang, In Hyuk, Ha, Yun-Sok, Bae, Eun Ju, Park, Byung-Hyun, Lee, Eun Hye, Kwon, Tae Gyun, Lee, Jun Nyung, Lee, Sangkyu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acetylation AKT protein Annotations Apoptosis - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Epigenesis, Genetic Gene Expression Regulation, Neoplastic Gene Knockout Techniques Genital cancers Humans IL-1β Immunoprecipitation Interleukins Male Metastases Metastasis NAD Phosphatidylinositol 3-Kinases - metabolism Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proteomics Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signal Transduction - genetics Sirtuins - genetics Sirtuins - metabolism Tumor cell lines
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