Direct Comparison of the Tau PET Tracers 18F-Flortaucipir and 18F-MK-6240 in Human Subjects

Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently used tau PET tracers, 18F-flortaucipir and 18F-MK-6240, in the same subjects. Methods: 18F-flortaucipir and 18F-MK-6240...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2022-01, Vol.63 (1), p.108-116
Hauptverfasser:	Gogola, Alexandra, Minhas, Davneet S, Villemagne, Victor L, Cohen, Ann D, Mountz, James M, Pascoal, Tharick A, Laymon, Charles M, Mason, N Scott, Ikonomovic, Milos D, Mathis, Chester A, Snitz, Beth E, Lopez, Oscar L, Klunk, William E, Lopresti, Brian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Binding Cerebellum Cerebral cortex Choroid plexus Clinical Investigation Cognition Dynamic range Longitudinal studies Medical imaging Meninges Neocortex Neostriatum Neurodegenerative diseases Pathology Positron emission Positron emission tomography Radioactive tracers Substantia grisea Tau protein Temporal lobe Tomography
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