The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer
Purpose of Review Malnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in pa...
Gespeichert in:
| Veröffentlicht in: | Current oncology reports 2020-05, Vol.22 (6), p.54-54, Article 54 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 54 |
|---|---|
| container_issue | 6 |
| container_start_page | 54 |
| container_title | Current oncology reports |
| container_volume | 22 |
| creator | Jain, Rishi Coss, Chris Whooley, Peter Phelps, Mitch Owen, Dwight H. |
| description | Purpose of Review
Malnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in patients with advanced lung cancer.
Recent Findings
While rates of malnutrition are high, nutritional intervention studies have generally been limited by small sample sizes. Novel strategies such as home-based meal delivery may have promise. While no therapy is approved for cancer cachexia, ghrelin agonists and other targeted therapies have yielded promising data in clinical trials. Recent data also suggest that obesity may improve immunotherapy responsiveness.
Summary
Malnutrition and associated muscle wasting are clearly negative prognostic markers in advanced lung cancer. Patients with malnutrition should be urgently referred for dietary counseling and guidelines for nutritional support should be followed. Optimal treatment of these syndromes will likely include nutrition and anti-cachexia interventions used in combination. |
| doi_str_mv | 10.1007/s11912-020-00916-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8717049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2404042035</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-95931f382eba64962d51eb164a4639e9ac3da956a1081ab36a84da3d5cc091fc3</originalsourceid><addsrcrecordid>eNp9kU1LJDEQhsOy4sesf2AP0uDFS6-Vj053LoIMri6MCKJ4DDXp9ExLTzIm3YL_3vTOrF-HJYcUqafeStVLyE8KvyhAeRopVZTlwCAHUFTm6hvZpwUXuWRSfR9jxnNeKtgjBzE-QiKhgl2yx5kApaDcJ9O7pc1ufWcz32TX2LmhD23fepehq7PrIZqUesDYt26RtS47r5_RGVtnsyE9TMc4_CA7DXbRHm7vCbn_fXE3vcpnN5d_puez3IhS9LkqFKcNr5idoxRKsrqgdk6lQCG5sgoNr1EVEilUFOdcYiVq5HVhTJquMXxCzja662G-srWxrg_Y6XVoVxhetMdWf864dqkX_llXJS1BqCRwshUI_mmwsderNhrbdeisH6JOW0mHAS8SevwFffRDcGm8kWLVaMAoyDaUCT7GYJu3z1DQI6I3Hum0ef3XIz0WHX0c463knykJ4BsgppRb2PDe-z-yr8Nsm14</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2402810079</pqid></control><display><type>article</type><title>The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Jain, Rishi ; Coss, Chris ; Whooley, Peter ; Phelps, Mitch ; Owen, Dwight H.</creator><creatorcontrib>Jain, Rishi ; Coss, Chris ; Whooley, Peter ; Phelps, Mitch ; Owen, Dwight H.</creatorcontrib><description>Purpose of Review
Malnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in patients with advanced lung cancer.
Recent Findings
While rates of malnutrition are high, nutritional intervention studies have generally been limited by small sample sizes. Novel strategies such as home-based meal delivery may have promise. While no therapy is approved for cancer cachexia, ghrelin agonists and other targeted therapies have yielded promising data in clinical trials. Recent data also suggest that obesity may improve immunotherapy responsiveness.
Summary
Malnutrition and associated muscle wasting are clearly negative prognostic markers in advanced lung cancer. Patients with malnutrition should be urgently referred for dietary counseling and guidelines for nutritional support should be followed. Optimal treatment of these syndromes will likely include nutrition and anti-cachexia interventions used in combination.</description><identifier>ISSN: 1523-3790</identifier><identifier>EISSN: 1534-6269</identifier><identifier>DOI: 10.1007/s11912-020-00916-9</identifier><identifier>PMID: 32409907</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Body Mass Index ; Cachexia ; Cachexia - drug therapy ; Cachexia - etiology ; Cancer therapies ; Chemotherapy ; Clinical trials ; Ghrelin ; Ghrelin - antagonists & inhibitors ; Humans ; Immunotherapy ; Lung cancer ; Lung Cancer (H Borghaei ; Lung Neoplasms - complications ; Lung Neoplasms - therapy ; Malnutrition ; Malnutrition - epidemiology ; Malnutrition - therapy ; Medicine ; Medicine & Public Health ; Nutrition ; Nutrition Assessment ; Obesity - complications ; Oncology ; Patients ; Sarcopenia ; Section Editor ; Topical Collection on Lung Cancer</subject><ispartof>Current oncology reports, 2020-05, Vol.22 (6), p.54-54, Article 54</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-95931f382eba64962d51eb164a4639e9ac3da956a1081ab36a84da3d5cc091fc3</citedby><cites>FETCH-LOGICAL-c474t-95931f382eba64962d51eb164a4639e9ac3da956a1081ab36a84da3d5cc091fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11912-020-00916-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11912-020-00916-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32409907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, Rishi</creatorcontrib><creatorcontrib>Coss, Chris</creatorcontrib><creatorcontrib>Whooley, Peter</creatorcontrib><creatorcontrib>Phelps, Mitch</creatorcontrib><creatorcontrib>Owen, Dwight H.</creatorcontrib><title>The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer</title><title>Current oncology reports</title><addtitle>Curr Oncol Rep</addtitle><addtitle>Curr Oncol Rep</addtitle><description>Purpose of Review
Malnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in patients with advanced lung cancer.
Recent Findings
While rates of malnutrition are high, nutritional intervention studies have generally been limited by small sample sizes. Novel strategies such as home-based meal delivery may have promise. While no therapy is approved for cancer cachexia, ghrelin agonists and other targeted therapies have yielded promising data in clinical trials. Recent data also suggest that obesity may improve immunotherapy responsiveness.
Summary
Malnutrition and associated muscle wasting are clearly negative prognostic markers in advanced lung cancer. Patients with malnutrition should be urgently referred for dietary counseling and guidelines for nutritional support should be followed. Optimal treatment of these syndromes will likely include nutrition and anti-cachexia interventions used in combination.</description><subject>Animals</subject><subject>Body Mass Index</subject><subject>Cachexia</subject><subject>Cachexia - drug therapy</subject><subject>Cachexia - etiology</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Ghrelin</subject><subject>Ghrelin - antagonists & inhibitors</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Lung cancer</subject><subject>Lung Cancer (H Borghaei</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - therapy</subject><subject>Malnutrition</subject><subject>Malnutrition - epidemiology</subject><subject>Malnutrition - therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Obesity - complications</subject><subject>Oncology</subject><subject>Patients</subject><subject>Sarcopenia</subject><subject>Section Editor</subject><subject>Topical Collection on Lung Cancer</subject><issn>1523-3790</issn><issn>1534-6269</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1LJDEQhsOy4sesf2AP0uDFS6-Vj053LoIMri6MCKJ4DDXp9ExLTzIm3YL_3vTOrF-HJYcUqafeStVLyE8KvyhAeRopVZTlwCAHUFTm6hvZpwUXuWRSfR9jxnNeKtgjBzE-QiKhgl2yx5kApaDcJ9O7pc1ufWcz32TX2LmhD23fepehq7PrIZqUesDYt26RtS47r5_RGVtnsyE9TMc4_CA7DXbRHm7vCbn_fXE3vcpnN5d_puez3IhS9LkqFKcNr5idoxRKsrqgdk6lQCG5sgoNr1EVEilUFOdcYiVq5HVhTJquMXxCzja662G-srWxrg_Y6XVoVxhetMdWf864dqkX_llXJS1BqCRwshUI_mmwsderNhrbdeisH6JOW0mHAS8SevwFffRDcGm8kWLVaMAoyDaUCT7GYJu3z1DQI6I3Hum0ef3XIz0WHX0c463knykJ4BsgppRb2PDe-z-yr8Nsm14</recordid><startdate>20200515</startdate><enddate>20200515</enddate><creator>Jain, Rishi</creator><creator>Coss, Chris</creator><creator>Whooley, Peter</creator><creator>Phelps, Mitch</creator><creator>Owen, Dwight H.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200515</creationdate><title>The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer</title><author>Jain, Rishi ; Coss, Chris ; Whooley, Peter ; Phelps, Mitch ; Owen, Dwight H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-95931f382eba64962d51eb164a4639e9ac3da956a1081ab36a84da3d5cc091fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Body Mass Index</topic><topic>Cachexia</topic><topic>Cachexia - drug therapy</topic><topic>Cachexia - etiology</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Ghrelin</topic><topic>Ghrelin - antagonists & inhibitors</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Lung cancer</topic><topic>Lung Cancer (H Borghaei</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - therapy</topic><topic>Malnutrition</topic><topic>Malnutrition - epidemiology</topic><topic>Malnutrition - therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Obesity - complications</topic><topic>Oncology</topic><topic>Patients</topic><topic>Sarcopenia</topic><topic>Section Editor</topic><topic>Topical Collection on Lung Cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, Rishi</creatorcontrib><creatorcontrib>Coss, Chris</creatorcontrib><creatorcontrib>Whooley, Peter</creatorcontrib><creatorcontrib>Phelps, Mitch</creatorcontrib><creatorcontrib>Owen, Dwight H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, Rishi</au><au>Coss, Chris</au><au>Whooley, Peter</au><au>Phelps, Mitch</au><au>Owen, Dwight H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer</atitle><jtitle>Current oncology reports</jtitle><stitle>Curr Oncol Rep</stitle><addtitle>Curr Oncol Rep</addtitle><date>2020-05-15</date><risdate>2020</risdate><volume>22</volume><issue>6</issue><spage>54</spage><epage>54</epage><pages>54-54</pages><artnum>54</artnum><issn>1523-3790</issn><eissn>1534-6269</eissn><abstract>Purpose of Review
Malnutrition, cancer cachexia, and sarcopenia often co-occur in patients with advanced cancer and are associated with poorer response to chemotherapy and reduced survival. Here, we evaluate the current literature regarding the role of nutrition and these associated conditions in patients with advanced lung cancer.
Recent Findings
While rates of malnutrition are high, nutritional intervention studies have generally been limited by small sample sizes. Novel strategies such as home-based meal delivery may have promise. While no therapy is approved for cancer cachexia, ghrelin agonists and other targeted therapies have yielded promising data in clinical trials. Recent data also suggest that obesity may improve immunotherapy responsiveness.
Summary
Malnutrition and associated muscle wasting are clearly negative prognostic markers in advanced lung cancer. Patients with malnutrition should be urgently referred for dietary counseling and guidelines for nutritional support should be followed. Optimal treatment of these syndromes will likely include nutrition and anti-cachexia interventions used in combination.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32409907</pmid><doi>10.1007/s11912-020-00916-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-3790 |
| ispartof | Current oncology reports, 2020-05, Vol.22 (6), p.54-54, Article 54 |
| issn | 1523-3790 1534-6269 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8717049 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Body Mass Index Cachexia Cachexia - drug therapy Cachexia - etiology Cancer therapies Chemotherapy Clinical trials Ghrelin Ghrelin - antagonists & inhibitors Humans Immunotherapy Lung cancer Lung Cancer (H Borghaei Lung Neoplasms - complications Lung Neoplasms - therapy Malnutrition Malnutrition - epidemiology Malnutrition - therapy Medicine Medicine & Public Health Nutrition Nutrition Assessment Obesity - complications Oncology Patients Sarcopenia Section Editor Topical Collection on Lung Cancer |
| title | The Role of Malnutrition and Muscle Wasting in Advanced Lung Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T11%3A30%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20Malnutrition%20and%20Muscle%20Wasting%20in%20Advanced%20Lung%20Cancer&rft.jtitle=Current%20oncology%20reports&rft.au=Jain,%20Rishi&rft.date=2020-05-15&rft.volume=22&rft.issue=6&rft.spage=54&rft.epage=54&rft.pages=54-54&rft.artnum=54&rft.issn=1523-3790&rft.eissn=1534-6269&rft_id=info:doi/10.1007/s11912-020-00916-9&rft_dat=%3Cproquest_pubme%3E2404042035%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2402810079&rft_id=info:pmid/32409907&rfr_iscdi=true |