Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

Bacillus anthracis lethal toxin and edema toxin are binary toxins that consist of a common cell-binding moiety, protective antigen (PA), and the enzymatic moieties, lethal factor (LF) and edema factor (EF). PA binds to either of two receptors, capillary morphogenesis protein-2 (CMG-2) or tumor endot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2022-01, Vol.298 (1), p.101467-101467, Article 101467
Hauptverfasser:	Merritt, Carly, Chun, Elizabeth M., Fattah, Rasem J., Silva, Lakmali M., Ma, Quinn Q., Moayeri, Mahtab, Paliga, Dennis, Neumann, Sebastian, Heumann, Rolf, Leppla, Stephen H., Bugge, Thomas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax - diagnostic imaging Anthrax - metabolism anthrax toxin Antigens, Bacterial - chemistry Antigens, Bacterial - toxicity Bacillus anthracis - metabolism Bacterial Toxins - toxicity CMG-2 confocal microscopy Cre recombinase Cre reporter mice Cytoplasm - metabolism Mice Mice, Transgenic TEM-8 whole-animal imaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!