Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy
Objectives Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF). Methods We retrospectively...
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| Veröffentlicht in: | Echocardiography (Mount Kisco, N.Y.) N.Y.), 2021-06, Vol.38 (6), p.885-891 |
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| container_title | Echocardiography (Mount Kisco, N.Y.) |
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| creator | Bortnick, Anna E. Lama von Buchwald, Claudia Hasani, Aliaskar Liu, Christina Berkowitz, Julia L. Vega, Shayna Mustehsan, Mohammad Hashim Wolfe, Diana S. Taub, Cynthia |
| description | Objectives
Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF).
Methods
We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999‐2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow‐up echocardiogram suitable for GLS analysis.
Results
Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was −13.2 (−14, −7.6)%. At a mean follow‐up time of 1.2 ± 0.7 years, 11/13 had persistently mild −15.6 (−16.3, −12.7)%, and 2/13 severely abnormal GLS −7.05 (−7.1, −7.0)%. There was no correlation between baseline GLS and ∆LVEF (r = .014, P = .965).
Conclusions
Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM. |
| doi_str_mv | 10.1111/echo.15071 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8715768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2524355736</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4201-875d3a499cf02458d0cedff0b9769ba6af41294beb2ac47359f9a6d131d9b65e3</originalsourceid><addsrcrecordid>eNp9kUtL9DAUhoMoOl42_gDpUj6o5to0G0EGbyDoQjduQpqezkTapibtJ_PvjY6Kbgwhh5CH5xzyInRI8AlJ6xTs0p8QgSXZQDMiOM5LIsUmmmHJaU5LSnfQbozPGCeE8G20w5gqmCzlDD3dQ4gujtBbyHyTmar3oTNttmh9lUrr-4Ubp9r16RLHYFyfpf3qO0inG5fZAMENJoxTl1kTaue7lR_MuFzto63GtBEOPuseery8eJhf57d3Vzfz89vccopJXkpRM8OVsg2mXJQ1tlA3Da6ULFRlCtNwQhWvoKLGcsmEapQpasJIrapCANtDZ2vvMFUd1Bb6NGarh-A6E1baG6d_v_RuqRf-vy4lEbIok-D4UxD8ywRx1J2LFtrW9OCnqKmgnAkhWZHQf2vUBh9jgOa7DcH6PQz9Hob-CCPBRz8H-0a_fj8BZA28uhZWf6j0xfz6bi19A_-2l_E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2524355736</pqid></control><display><type>article</type><title>Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Bortnick, Anna E. ; Lama von Buchwald, Claudia ; Hasani, Aliaskar ; Liu, Christina ; Berkowitz, Julia L. ; Vega, Shayna ; Mustehsan, Mohammad Hashim ; Wolfe, Diana S. ; Taub, Cynthia</creator><creatorcontrib>Bortnick, Anna E. ; Lama von Buchwald, Claudia ; Hasani, Aliaskar ; Liu, Christina ; Berkowitz, Julia L. ; Vega, Shayna ; Mustehsan, Mohammad Hashim ; Wolfe, Diana S. ; Taub, Cynthia</creatorcontrib><description>Objectives
Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF).
Methods
We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999‐2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow‐up echocardiogram suitable for GLS analysis.
Results
Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was −13.2 (−14, −7.6)%. At a mean follow‐up time of 1.2 ± 0.7 years, 11/13 had persistently mild −15.6 (−16.3, −12.7)%, and 2/13 severely abnormal GLS −7.05 (−7.1, −7.0)%. There was no correlation between baseline GLS and ∆LVEF (r = .014, P = .965).
Conclusions
Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM.</description><identifier>ISSN: 0742-2822</identifier><identifier>ISSN: 1540-8175</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.15071</identifier><identifier>PMID: 33963787</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Cardiomyopathies - complications ; Cardiomyopathies - diagnostic imaging ; cardiomyopathy ; echocardiogram ; Female ; heart failure ; Humans ; Peripartum Period ; pregnancy ; Retrospective Studies ; Stroke Volume ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Function, Left ; Young Adult</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2021-06, Vol.38 (6), p.885-891</ispartof><rights>2021 Wiley Periodicals LLC</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4201-875d3a499cf02458d0cedff0b9769ba6af41294beb2ac47359f9a6d131d9b65e3</citedby><cites>FETCH-LOGICAL-c4201-875d3a499cf02458d0cedff0b9769ba6af41294beb2ac47359f9a6d131d9b65e3</cites><orcidid>0000-0003-4019-9678 ; 0000-0001-7983-5243</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.15071$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.15071$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33963787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bortnick, Anna E.</creatorcontrib><creatorcontrib>Lama von Buchwald, Claudia</creatorcontrib><creatorcontrib>Hasani, Aliaskar</creatorcontrib><creatorcontrib>Liu, Christina</creatorcontrib><creatorcontrib>Berkowitz, Julia L.</creatorcontrib><creatorcontrib>Vega, Shayna</creatorcontrib><creatorcontrib>Mustehsan, Mohammad Hashim</creatorcontrib><creatorcontrib>Wolfe, Diana S.</creatorcontrib><creatorcontrib>Taub, Cynthia</creatorcontrib><title>Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>Echocardiography</addtitle><description>Objectives
Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF).
Methods
We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999‐2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow‐up echocardiogram suitable for GLS analysis.
Results
Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was −13.2 (−14, −7.6)%. At a mean follow‐up time of 1.2 ± 0.7 years, 11/13 had persistently mild −15.6 (−16.3, −12.7)%, and 2/13 severely abnormal GLS −7.05 (−7.1, −7.0)%. There was no correlation between baseline GLS and ∆LVEF (r = .014, P = .965).
Conclusions
Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>cardiomyopathy</subject><subject>echocardiogram</subject><subject>Female</subject><subject>heart failure</subject><subject>Humans</subject><subject>Peripartum Period</subject><subject>pregnancy</subject><subject>Retrospective Studies</subject><subject>Stroke Volume</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Function, Left</subject><subject>Young Adult</subject><issn>0742-2822</issn><issn>1540-8175</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtL9DAUhoMoOl42_gDpUj6o5to0G0EGbyDoQjduQpqezkTapibtJ_PvjY6Kbgwhh5CH5xzyInRI8AlJ6xTs0p8QgSXZQDMiOM5LIsUmmmHJaU5LSnfQbozPGCeE8G20w5gqmCzlDD3dQ4gujtBbyHyTmar3oTNttmh9lUrr-4Ubp9r16RLHYFyfpf3qO0inG5fZAMENJoxTl1kTaue7lR_MuFzto63GtBEOPuseery8eJhf57d3Vzfz89vccopJXkpRM8OVsg2mXJQ1tlA3Da6ULFRlCtNwQhWvoKLGcsmEapQpasJIrapCANtDZ2vvMFUd1Bb6NGarh-A6E1baG6d_v_RuqRf-vy4lEbIok-D4UxD8ywRx1J2LFtrW9OCnqKmgnAkhWZHQf2vUBh9jgOa7DcH6PQz9Hob-CCPBRz8H-0a_fj8BZA28uhZWf6j0xfz6bi19A_-2l_E</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Bortnick, Anna E.</creator><creator>Lama von Buchwald, Claudia</creator><creator>Hasani, Aliaskar</creator><creator>Liu, Christina</creator><creator>Berkowitz, Julia L.</creator><creator>Vega, Shayna</creator><creator>Mustehsan, Mohammad Hashim</creator><creator>Wolfe, Diana S.</creator><creator>Taub, Cynthia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4019-9678</orcidid><orcidid>https://orcid.org/0000-0001-7983-5243</orcidid></search><sort><creationdate>202106</creationdate><title>Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy</title><author>Bortnick, Anna E. ; Lama von Buchwald, Claudia ; Hasani, Aliaskar ; Liu, Christina ; Berkowitz, Julia L. ; Vega, Shayna ; Mustehsan, Mohammad Hashim ; Wolfe, Diana S. ; Taub, Cynthia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4201-875d3a499cf02458d0cedff0b9769ba6af41294beb2ac47359f9a6d131d9b65e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - diagnostic imaging</topic><topic>cardiomyopathy</topic><topic>echocardiogram</topic><topic>Female</topic><topic>heart failure</topic><topic>Humans</topic><topic>Peripartum Period</topic><topic>pregnancy</topic><topic>Retrospective Studies</topic><topic>Stroke Volume</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Function, Left</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bortnick, Anna E.</creatorcontrib><creatorcontrib>Lama von Buchwald, Claudia</creatorcontrib><creatorcontrib>Hasani, Aliaskar</creatorcontrib><creatorcontrib>Liu, Christina</creatorcontrib><creatorcontrib>Berkowitz, Julia L.</creatorcontrib><creatorcontrib>Vega, Shayna</creatorcontrib><creatorcontrib>Mustehsan, Mohammad Hashim</creatorcontrib><creatorcontrib>Wolfe, Diana S.</creatorcontrib><creatorcontrib>Taub, Cynthia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bortnick, Anna E.</au><au>Lama von Buchwald, Claudia</au><au>Hasani, Aliaskar</au><au>Liu, Christina</au><au>Berkowitz, Julia L.</au><au>Vega, Shayna</au><au>Mustehsan, Mohammad Hashim</au><au>Wolfe, Diana S.</au><au>Taub, Cynthia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><addtitle>Echocardiography</addtitle><date>2021-06</date><risdate>2021</risdate><volume>38</volume><issue>6</issue><spage>885</spage><epage>891</epage><pages>885-891</pages><issn>0742-2822</issn><issn>1540-8175</issn><eissn>1540-8175</eissn><abstract>Objectives
Data regarding the longitudinal relationship of global longitudinal strain (GLS) and echocardiographic parameters are lacking in peripartum cardiomyopathy (PPCM). We evaluated GLS and its correlation with change (∆) in left ventricular ejection fraction (LVEF).
Methods
We retrospectively identified women age ≥16 years hospitalized at Montefiore Medical Center in Bronx, NY from 1999‐2015 with International Statistical Classification of Diseases and Related Health Problems, 9th revision codes for PPCM or an occurrence of unexplained heart failure during or up to 5 months postpartum. N = 195 charts were reviewed for inclusion/exclusion criteria, n = 53 patients met criteria for PPCM, and of those, n = 13 had a baseline and follow‐up echocardiogram suitable for GLS analysis.
Results
Of those eligible for strain analysis, the mean age was 30 ± 6 years, 46.2% identified as Black and 38.5% as Hispanic/Latina. Baseline LVEF was 30 (25, 35)%, GLS was −13.2 (−14, −7.6)%. At a mean follow‐up time of 1.2 ± 0.7 years, 11/13 had persistently mild −15.6 (−16.3, −12.7)%, and 2/13 severely abnormal GLS −7.05 (−7.1, −7.0)%. There was no correlation between baseline GLS and ∆LVEF (r = .014, P = .965).
Conclusions
Global longitudinal strain is a sensitive method to identify subclinical myocardial dysfunction. In this series of women with PPCM, GLS remained persistently abnormal over time, even if LVEF improved. Future studies should examine the implication of persistently abnormal GLS in PPCM.</abstract><cop>United States</cop><pmid>33963787</pmid><doi>10.1111/echo.15071</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4019-9678</orcidid><orcidid>https://orcid.org/0000-0001-7983-5243</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Cardiomyopathies - complications Cardiomyopathies - diagnostic imaging cardiomyopathy echocardiogram Female heart failure Humans Peripartum Period pregnancy Retrospective Studies Stroke Volume Ventricular Dysfunction, Left - diagnostic imaging Ventricular Function, Left Young Adult |
| title | Persistence of abnormal global longitudinal strain in women with peripartum cardiomyopathy |
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