IgG1 conformational behavior: elucidation of the N-glycosylation role via molecular dynamics

Currently, monoclonal antibodies (mAbs) are the most used biopharmaceuticals for human therapy. One of the key aspects in their development is the control of effector functions mediated by the interaction between fragment crystallizable (Fc) and Fcγ receptors, which is a secondary mechanism of the a...

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Veröffentlicht in:	Biophysical journal 2021-12, Vol.120 (23), p.5355-5370
Hauptverfasser:	Saporiti, Simona, Parravicini, Chiara, Pergola, Carlo, Guerrini, Uliano, Rossi, Mara, Centola, Fabio, Eberini, Ivano
Format:	Artikel
Sprache:	eng
Schlagworte:	Fucose Glycosylation Humans Immunoglobulin Fc Fragments - metabolism Immunoglobulin G - metabolism Molecular Dynamics Simulation
Online-Zugang:	Volltext
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