Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity
Sex-related differences in respiratory modulation of sympathetic activity have been observed in rodent models of sleep apnea [intermittent hypoxia (IH)]. In light of sex disparities in the respiratory response to acute IH in humans as well as changes in respiratory modulation of muscle sympathetic n...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2021-12, Vol.321 (6), p.R903-R911 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Edmunds, Jane S Ivie, Clayton L Ott, Elizabeth P Jacob, Dain W Baker, Sarah E Harper, Jennifer L Manrique-Acevedo, Camila M Limberg, Jacqueline K |
| description | Sex-related differences in respiratory modulation of sympathetic activity have been observed in rodent models of sleep apnea [intermittent hypoxia (IH)]. In light of sex disparities in the respiratory response to acute IH in humans as well as changes in respiratory modulation of muscle sympathetic nerve activity (MSNA) in clinical sleep apnea, we examined sex-related differences in respiratory modulation of MSNA following acute IH. We hypothesized that respiratory modulation of MSNA would be altered in both male and female participants after IH; however, the respiratory patterning of MSNA following IH would be sex specific. Heart rate, MSNA, and respiration were evaluated in healthy male (
= 21, 30 ± 5 yr) and female (
= 10, 28 ± 5 yr) participants during normoxic rest before and after 30 min of IH. Respiratory modulation of MSNA was assessed by fitting polynomials to cross-correlation histograms constructed between sympathetic spikes and respiration. MSNA was elevated after IH in male (20 ± 6 to 24 ± 8 bursts/min) and female (19 ± 8 to 22 ± 10 bursts/min) participants (
< 0.01). Both male and female participants exhibited respiratory modulation of MSNA (
< 0.01); however, the pattern differed by sex. After IH, modulation of MSNA within the breath was reduced in male participants (
= 0.03) but increased in female participants (
= 0.02). Both male and female adults exhibit changes in respiratory patterning of MSNA after acute IH; however, this pattern differs by sex. These data support sex disparities in respiratory modulation of MSNA and may have implications for conditions such as sleep apnea. |
| doi_str_mv | 10.1152/ajpregu.00042.2021 |
| format | Article |
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= 21, 30 ± 5 yr) and female (
= 10, 28 ± 5 yr) participants during normoxic rest before and after 30 min of IH. Respiratory modulation of MSNA was assessed by fitting polynomials to cross-correlation histograms constructed between sympathetic spikes and respiration. MSNA was elevated after IH in male (20 ± 6 to 24 ± 8 bursts/min) and female (19 ± 8 to 22 ± 10 bursts/min) participants (
< 0.01). Both male and female participants exhibited respiratory modulation of MSNA (
< 0.01); however, the pattern differed by sex. After IH, modulation of MSNA within the breath was reduced in male participants (
= 0.03) but increased in female participants (
= 0.02). Both male and female adults exhibit changes in respiratory patterning of MSNA after acute IH; however, this pattern differs by sex. These data support sex disparities in respiratory modulation of MSNA and may have implications for conditions such as sleep apnea.</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00042.2021</identifier><identifier>PMID: 34668438</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adaptation, Physiological ; Adult ; Animal models ; Apnea ; Biomarkers - blood ; Bursts ; Cross correlation ; Female ; Gender aspects ; Gender differences ; Heart Rate ; Histograms ; Humans ; Hypoxia ; Hypoxia - blood ; Hypoxia - physiopathology ; Lung - innervation ; Male ; Males ; Modulation ; Muscle, Skeletal - innervation ; Muscles ; Oxygen - blood ; Patterning ; Polynomials ; Respiration ; Respiratory Mechanics ; Sex differences ; Sex Factors ; Sleep ; Sleep apnea ; Sleep disorders ; Sympathetic nerves ; Sympathetic Nervous System - physiopathology ; Time Factors ; Young Adult</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2021-12, Vol.321 (6), p.R903-R911</ispartof><rights>Copyright American Physiological Society Dec 2021</rights><rights>Published by the American Physiological Society. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-6601bd2f9d42a5775b509524768fa84855f18b200761eb5f2c68277b209fc9523</citedby><cites>FETCH-LOGICAL-c430t-6601bd2f9d42a5775b509524768fa84855f18b200761eb5f2c68277b209fc9523</cites><orcidid>0000-0001-9341-404X ; 0000-0001-9982-5851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34668438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edmunds, Jane S</creatorcontrib><creatorcontrib>Ivie, Clayton L</creatorcontrib><creatorcontrib>Ott, Elizabeth P</creatorcontrib><creatorcontrib>Jacob, Dain W</creatorcontrib><creatorcontrib>Baker, Sarah E</creatorcontrib><creatorcontrib>Harper, Jennifer L</creatorcontrib><creatorcontrib>Manrique-Acevedo, Camila M</creatorcontrib><creatorcontrib>Limberg, Jacqueline K</creatorcontrib><title>Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Sex-related differences in respiratory modulation of sympathetic activity have been observed in rodent models of sleep apnea [intermittent hypoxia (IH)]. In light of sex disparities in the respiratory response to acute IH in humans as well as changes in respiratory modulation of muscle sympathetic nerve activity (MSNA) in clinical sleep apnea, we examined sex-related differences in respiratory modulation of MSNA following acute IH. We hypothesized that respiratory modulation of MSNA would be altered in both male and female participants after IH; however, the respiratory patterning of MSNA following IH would be sex specific. Heart rate, MSNA, and respiration were evaluated in healthy male (
= 21, 30 ± 5 yr) and female (
= 10, 28 ± 5 yr) participants during normoxic rest before and after 30 min of IH. Respiratory modulation of MSNA was assessed by fitting polynomials to cross-correlation histograms constructed between sympathetic spikes and respiration. MSNA was elevated after IH in male (20 ± 6 to 24 ± 8 bursts/min) and female (19 ± 8 to 22 ± 10 bursts/min) participants (
< 0.01). Both male and female participants exhibited respiratory modulation of MSNA (
< 0.01); however, the pattern differed by sex. After IH, modulation of MSNA within the breath was reduced in male participants (
= 0.03) but increased in female participants (
= 0.02). Both male and female adults exhibit changes in respiratory patterning of MSNA after acute IH; however, this pattern differs by sex. These data support sex disparities in respiratory modulation of MSNA and may have implications for conditions such as sleep apnea.</description><subject>Adaptation, Physiological</subject><subject>Adult</subject><subject>Animal models</subject><subject>Apnea</subject><subject>Biomarkers - blood</subject><subject>Bursts</subject><subject>Cross correlation</subject><subject>Female</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Heart Rate</subject><subject>Histograms</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia - blood</subject><subject>Hypoxia - physiopathology</subject><subject>Lung - innervation</subject><subject>Male</subject><subject>Males</subject><subject>Modulation</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscles</subject><subject>Oxygen - blood</subject><subject>Patterning</subject><subject>Polynomials</subject><subject>Respiration</subject><subject>Respiratory Mechanics</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep disorders</subject><subject>Sympathetic nerves</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUuLFDEUhYMoTjv6B1xIwI2bavOu1EaQwRcMuFDXIZW6mU5TVSmT1DD170077aCuLpz7ncO9HIReUrKnVLK39rgkuFn3hBDB9oww-gjt6oI1VHTkMdoRrnijKO0u0LOcjyeOC_4UXXChlBZc79D0De7wELyHBLODjMOMywEwVMUVHD22bi1Q5QJpCqXAXPBhW-JdsDjOOEFeQrIlpg1PcVhHW0KVqy9v02JrVAmuZpRwG8r2HD3xdszw4jwv0Y-PH75ffW6uv376cvX-unGCk9IoRWg_MN8NglnZtrKXpJNMtEp7q4WW0lPdM0JaRaGXnjmlWdtWpfOugvwSvbvPXdZ-gsHVo5MdzZLCZNNmog3m380cDuYm3hrdUqEprQFvzgEp_lwhFzOF7GAc7QxxzYZJLQhtheQVff0feoxrmut7hikiORGUyUqxe8qlmHMC_3AMJebUpjm3aX63aU5tVtOrv994sPypj_8Cc3Cefg</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Edmunds, Jane S</creator><creator>Ivie, Clayton L</creator><creator>Ott, Elizabeth P</creator><creator>Jacob, Dain W</creator><creator>Baker, Sarah E</creator><creator>Harper, Jennifer L</creator><creator>Manrique-Acevedo, Camila M</creator><creator>Limberg, Jacqueline K</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9341-404X</orcidid><orcidid>https://orcid.org/0000-0001-9982-5851</orcidid></search><sort><creationdate>20211201</creationdate><title>Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity</title><author>Edmunds, Jane S ; Ivie, Clayton L ; Ott, Elizabeth P ; Jacob, Dain W ; Baker, Sarah E ; Harper, Jennifer L ; Manrique-Acevedo, Camila M ; Limberg, Jacqueline K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-6601bd2f9d42a5775b509524768fa84855f18b200761eb5f2c68277b209fc9523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptation, Physiological</topic><topic>Adult</topic><topic>Animal models</topic><topic>Apnea</topic><topic>Biomarkers - blood</topic><topic>Bursts</topic><topic>Cross correlation</topic><topic>Female</topic><topic>Gender aspects</topic><topic>Gender differences</topic><topic>Heart Rate</topic><topic>Histograms</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia - blood</topic><topic>Hypoxia - physiopathology</topic><topic>Lung - innervation</topic><topic>Male</topic><topic>Males</topic><topic>Modulation</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscles</topic><topic>Oxygen - blood</topic><topic>Patterning</topic><topic>Polynomials</topic><topic>Respiration</topic><topic>Respiratory Mechanics</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep disorders</topic><topic>Sympathetic nerves</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edmunds, Jane S</creatorcontrib><creatorcontrib>Ivie, Clayton L</creatorcontrib><creatorcontrib>Ott, Elizabeth P</creatorcontrib><creatorcontrib>Jacob, Dain W</creatorcontrib><creatorcontrib>Baker, Sarah E</creatorcontrib><creatorcontrib>Harper, Jennifer L</creatorcontrib><creatorcontrib>Manrique-Acevedo, Camila M</creatorcontrib><creatorcontrib>Limberg, Jacqueline K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edmunds, Jane S</au><au>Ivie, Clayton L</au><au>Ott, Elizabeth P</au><au>Jacob, Dain W</au><au>Baker, Sarah E</au><au>Harper, Jennifer L</au><au>Manrique-Acevedo, Camila M</au><au>Limberg, Jacqueline K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>321</volume><issue>6</issue><spage>R903</spage><epage>R911</epage><pages>R903-R911</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>Sex-related differences in respiratory modulation of sympathetic activity have been observed in rodent models of sleep apnea [intermittent hypoxia (IH)]. In light of sex disparities in the respiratory response to acute IH in humans as well as changes in respiratory modulation of muscle sympathetic nerve activity (MSNA) in clinical sleep apnea, we examined sex-related differences in respiratory modulation of MSNA following acute IH. We hypothesized that respiratory modulation of MSNA would be altered in both male and female participants after IH; however, the respiratory patterning of MSNA following IH would be sex specific. Heart rate, MSNA, and respiration were evaluated in healthy male (
= 21, 30 ± 5 yr) and female (
= 10, 28 ± 5 yr) participants during normoxic rest before and after 30 min of IH. Respiratory modulation of MSNA was assessed by fitting polynomials to cross-correlation histograms constructed between sympathetic spikes and respiration. MSNA was elevated after IH in male (20 ± 6 to 24 ± 8 bursts/min) and female (19 ± 8 to 22 ± 10 bursts/min) participants (
< 0.01). Both male and female participants exhibited respiratory modulation of MSNA (
< 0.01); however, the pattern differed by sex. After IH, modulation of MSNA within the breath was reduced in male participants (
= 0.03) but increased in female participants (
= 0.02). Both male and female adults exhibit changes in respiratory patterning of MSNA after acute IH; however, this pattern differs by sex. These data support sex disparities in respiratory modulation of MSNA and may have implications for conditions such as sleep apnea.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>34668438</pmid><doi>10.1152/ajpregu.00042.2021</doi><orcidid>https://orcid.org/0000-0001-9341-404X</orcidid><orcidid>https://orcid.org/0000-0001-9982-5851</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptation, Physiological Adult Animal models Apnea Biomarkers - blood Bursts Cross correlation Female Gender aspects Gender differences Heart Rate Histograms Humans Hypoxia Hypoxia - blood Hypoxia - physiopathology Lung - innervation Male Males Modulation Muscle, Skeletal - innervation Muscles Oxygen - blood Patterning Polynomials Respiration Respiratory Mechanics Sex differences Sex Factors Sleep Sleep apnea Sleep disorders Sympathetic nerves Sympathetic Nervous System - physiopathology Time Factors Young Adult |
| title | Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity |
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