The past, present, and future of enzyme-based therapies

•An overview of applications of enzyme based therapies (EBTs).•Provides historical, clinical, and regulatory context for EBT market growth and decline.•A review of both approved and investigational therapies.•Discusses challenges facing EBTs that could be addressed with enzyme engineering.•Specific,...

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Veröffentlicht in:	Drug discovery today 2022-01, Vol.27 (1), p.117-133
Hauptverfasser:	Hennigan, Jennifer N., Lynch, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biologic Biotechnology Clinical Drug Development - methods Drug Discovery - methods Early investigational Enzyme Enzyme based therapy Enzyme Replacement Therapy - methods Enzyme Replacement Therapy - trends Enzyme Therapy - methods Enzyme Therapy - trends Enzymes - classification Enzymes - pharmacology History Humans Pre-clinical Therapeutic enzymes Therapy
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