Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator

The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) protein family members have cytidine deaminase activity and can induce cytosine to uracil transition in nucleic acid. The main function of APOBEC3 (A3) proteins is to trigger an innate immune response to viral infections. R...

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Veröffentlicht in:	International journal of hematology 2020-09, Vol.112 (3), p.395-408
Hauptverfasser:	Takei, Hisashi, Fukuda, Hirofumi, Pan, Gilbert, Yamazaki, Hiroyuki, Matsumoto, Tadahiko, Kazuma, Yasuhiro, Fujii, Masanori, Nakayama, Sohei, Kobayashi, Ikei S., Shindo, Keisuke, Yamashita, Riu, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Kobayashi, Susumu S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Anti-Retroviral Agents Antiretroviral agents Apolipoprotein B Cell Line, Tumor Cells, Cultured Cytidine deaminase Cytidine Deaminase - chemistry Cytidine Deaminase - genetics Cytidine Deaminase - physiology Cytosine Deoxyribonucleic acid DNA DNA - genetics DNA End-Joining Repair - genetics Genetic Variation Genomics Hematology Humans Immune response Innate immunity Localization Medicine Medicine & Public Health mRNA Mutagenesis Mutation Mutation - genetics Nucleic acids Oncology Original Article Polypeptides Protein Domains Proteins RNA editing Uracil
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