Mandipropamid as a chemical inducer of proximity for in vivo applications

Direct control of protein interactions by chemically induced protein proximity holds great potential for both cell and synthetic biology as well as therapeutic applications. Low toxicity, orthogonality and excellent cell permeability are important criteria for chemical inducers of proximity (CIPs),...

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Veröffentlicht in:	Nature chemical biology 2022-01, Vol.18 (1), p.64-69
Hauptverfasser:	Ziegler, Michael J., Yserentant, Klaus, Dunsing, Valentin, Middel, Volker, Gralak, Antoni J., Pakari, Kaisa, Bargstedt, Jörn, Kern, Christoph, Petrich, Annett, Chiantia, Salvatore, Strähle, Uwe, Herten, Dirk-Peter, Wombacher, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/552 631/92/56 631/92/96 Abscisic acid Abscisic Acid - metabolism Agrochemicals Amides - pharmacology Animals Biochemical Engineering Biochemistry Biocompatibility Bioorganic Chemistry Carboxylic Acids - pharmacology Cell Biology Cell culture Cell permeability Chemistry Chemistry and Materials Science Chemistry/Food Science Complex formation Dimerization Embryos Fungicides, Industrial - pharmacology Mammalian cells Orthogonality Plant hormones Protein interaction Protein transport Proteins Proximity Rapamycin Receptors Therapeutic applications Toxicity Translocation Zebrafish Zebrafish - embryology
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