Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis
The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathologi...
Gespeichert in:
| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2021, Vol.2021, p.7004798-13 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13 |
|---|---|
| container_issue | |
| container_start_page | 7004798 |
| container_title | Evidence-based complementary and alternative medicine |
| container_volume | 2021 |
| creator | Tong, Yuling Jing, Manyi Zhao, Xu Liu, Honghong Wei, Shizhang Li, Ruisheng Liu, Xia Wang, Min Song, Hongtao Zhao, Yanling |
| description | The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs. |
| doi_str_mv | 10.1155/2021/7004798 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8709764</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2614758527</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-edae74b348b97372bf1b7e0912603ee26a85f9b39f5aa9f66914cc36b79889473</originalsourceid><addsrcrecordid>eNp9kUuLFDEUhYMozti6cy0FbgSNk1flsRkYGh0HRhQfIG5CqirVlSadtElqpP-9abpt1IWrc-F-nOSeA8BTjF5j3LYXBBF8IRBiQsl74BwLhiEjUt4_zeLbGXiU8xohooQQD8EZZarlVJJzUN7bYrro48b1zecyD7smjs33Oa5daD4675uqn6x39s6FVYNh5aedhxQGV1KE-KA5rmYT3OCChTdhmHs7NMspxVBdr-p-O9Xh2uSSXHH5MXgwGp_tk6MuwNe3b74s38HbD9c3y6tb2DMmC7SDsYJ1lMlOCSpIN-JOWKQw4YhaS7iR7ag6qsbWGDVyrjDre8q7moRUTNAFuDz4buduY4fehpKM19vkNibtdDRO_70JbtKreKelQEpwVg1eHA1S_DHbXPTG5d56b4KNc9aEYyZa2ZL9W8__QddxTqGet6eo4kTUyBfg1YHqa2Y52fH0GYz0vk69r1Mf66z4sz8POMG_-6vAywMwuTCYn-7_dr8AdHCofg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2613962756</pqid></control><display><type>article</type><title>Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis</title><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Tong, Yuling ; Jing, Manyi ; Zhao, Xu ; Liu, Honghong ; Wei, Shizhang ; Li, Ruisheng ; Liu, Xia ; Wang, Min ; Song, Hongtao ; Zhao, Yanling</creator><contributor>Arunachalam, K ; K Arunachalam</contributor><creatorcontrib>Tong, Yuling ; Jing, Manyi ; Zhao, Xu ; Liu, Honghong ; Wei, Shizhang ; Li, Ruisheng ; Liu, Xia ; Wang, Min ; Song, Hongtao ; Zhao, Yanling ; Arunachalam, K ; K Arunachalam</creatorcontrib><description>The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/7004798</identifier><identifier>PMID: 34956382</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Biomarkers ; Cancer ; Chromatography ; Cytokines ; Discriminant analysis ; Drug development ; Enzymes ; Gastritis ; Inflammation ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolomics ; Polymerase chain reaction ; Trinucleotide repeats ; Tumor necrosis factor-TNF ; Urine ; Variance analysis</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.7004798-13</ispartof><rights>Copyright © 2021 Yuling Tong et al.</rights><rights>Copyright © 2021 Yuling Tong et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Yuling Tong et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-edae74b348b97372bf1b7e0912603ee26a85f9b39f5aa9f66914cc36b79889473</citedby><cites>FETCH-LOGICAL-c448t-edae74b348b97372bf1b7e0912603ee26a85f9b39f5aa9f66914cc36b79889473</cites><orcidid>0000-0001-6225-4362 ; 0000-0003-1079-7896 ; 0000-0003-0069-8915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709764/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709764/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34956382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arunachalam, K</contributor><contributor>K Arunachalam</contributor><creatorcontrib>Tong, Yuling</creatorcontrib><creatorcontrib>Jing, Manyi</creatorcontrib><creatorcontrib>Zhao, Xu</creatorcontrib><creatorcontrib>Liu, Honghong</creatorcontrib><creatorcontrib>Wei, Shizhang</creatorcontrib><creatorcontrib>Li, Ruisheng</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Song, Hongtao</creatorcontrib><creatorcontrib>Zhao, Yanling</creatorcontrib><title>Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs.</description><subject>Biomarkers</subject><subject>Cancer</subject><subject>Chromatography</subject><subject>Cytokines</subject><subject>Discriminant analysis</subject><subject>Drug development</subject><subject>Enzymes</subject><subject>Gastritis</subject><subject>Inflammation</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Polymerase chain reaction</subject><subject>Trinucleotide repeats</subject><subject>Tumor necrosis factor-TNF</subject><subject>Urine</subject><subject>Variance analysis</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUuLFDEUhYMozti6cy0FbgSNk1flsRkYGh0HRhQfIG5CqirVlSadtElqpP-9abpt1IWrc-F-nOSeA8BTjF5j3LYXBBF8IRBiQsl74BwLhiEjUt4_zeLbGXiU8xohooQQD8EZZarlVJJzUN7bYrro48b1zecyD7smjs33Oa5daD4675uqn6x39s6FVYNh5aedhxQGV1KE-KA5rmYT3OCChTdhmHs7NMspxVBdr-p-O9Xh2uSSXHH5MXgwGp_tk6MuwNe3b74s38HbD9c3y6tb2DMmC7SDsYJ1lMlOCSpIN-JOWKQw4YhaS7iR7ag6qsbWGDVyrjDre8q7moRUTNAFuDz4buduY4fehpKM19vkNibtdDRO_70JbtKreKelQEpwVg1eHA1S_DHbXPTG5d56b4KNc9aEYyZa2ZL9W8__QddxTqGet6eo4kTUyBfg1YHqa2Y52fH0GYz0vk69r1Mf66z4sz8POMG_-6vAywMwuTCYn-7_dr8AdHCofg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Tong, Yuling</creator><creator>Jing, Manyi</creator><creator>Zhao, Xu</creator><creator>Liu, Honghong</creator><creator>Wei, Shizhang</creator><creator>Li, Ruisheng</creator><creator>Liu, Xia</creator><creator>Wang, Min</creator><creator>Song, Hongtao</creator><creator>Zhao, Yanling</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6225-4362</orcidid><orcidid>https://orcid.org/0000-0003-1079-7896</orcidid><orcidid>https://orcid.org/0000-0003-0069-8915</orcidid></search><sort><creationdate>2021</creationdate><title>Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis</title><author>Tong, Yuling ; Jing, Manyi ; Zhao, Xu ; Liu, Honghong ; Wei, Shizhang ; Li, Ruisheng ; Liu, Xia ; Wang, Min ; Song, Hongtao ; Zhao, Yanling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-edae74b348b97372bf1b7e0912603ee26a85f9b39f5aa9f66914cc36b79889473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Cancer</topic><topic>Chromatography</topic><topic>Cytokines</topic><topic>Discriminant analysis</topic><topic>Drug development</topic><topic>Enzymes</topic><topic>Gastritis</topic><topic>Inflammation</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Polymerase chain reaction</topic><topic>Trinucleotide repeats</topic><topic>Tumor necrosis factor-TNF</topic><topic>Urine</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Yuling</creatorcontrib><creatorcontrib>Jing, Manyi</creatorcontrib><creatorcontrib>Zhao, Xu</creatorcontrib><creatorcontrib>Liu, Honghong</creatorcontrib><creatorcontrib>Wei, Shizhang</creatorcontrib><creatorcontrib>Li, Ruisheng</creatorcontrib><creatorcontrib>Liu, Xia</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Song, Hongtao</creatorcontrib><creatorcontrib>Zhao, Yanling</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Yuling</au><au>Jing, Manyi</au><au>Zhao, Xu</au><au>Liu, Honghong</au><au>Wei, Shizhang</au><au>Li, Ruisheng</au><au>Liu, Xia</au><au>Wang, Min</au><au>Song, Hongtao</au><au>Zhao, Yanling</au><au>Arunachalam, K</au><au>K Arunachalam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>7004798</spage><epage>13</epage><pages>7004798-13</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The classic prescription Zuojin Pill (ZJP) shows a good therapeutic effect on chronic atrophic gastritis (CAG); it is of great significance to clarify its specific mechanism. Therefore, we explore the mechanism of ZJP on MNNG-induced CAG by integrating approaches. First of all, through the pathological changes of gastric tissue and the expression level of PGI and PGI/II in serum, the expression of inflammation-related factors was determined by RT-PCR to determine the efficacy. Then, UPLC-Q-TOF/MS was used for plasma and urine metabolomic analysis to screen the specific potential biomarkers and metabolic pathway of ZJP in ameliorating CAG and to explore its possible mechanism. ZJP significantly ameliorate the pathological injury of gastric tissue, increase levels of PGI and PGI/II, and reduce the expression level of proinflammatory factors. Through metabolomic analysis, 9 potential metabolic differences were identified and 6 related metabolic pathways were enriched. These findings indicate for the first time the potential mechanism of ZJP in improving CAG induced by MNNG and are of great significance to the clinical development and application of ZJP-related drugs.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34956382</pmid><doi>10.1155/2021/7004798</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6225-4362</orcidid><orcidid>https://orcid.org/0000-0003-1079-7896</orcidid><orcidid>https://orcid.org/0000-0003-0069-8915</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1741-427X |
| ispartof | Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.7004798-13 |
| issn | 1741-427X 1741-4288 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8709764 |
| source | PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Biomarkers Cancer Chromatography Cytokines Discriminant analysis Drug development Enzymes Gastritis Inflammation Metabolic pathways Metabolism Metabolites Metabolomics Polymerase chain reaction Trinucleotide repeats Tumor necrosis factor-TNF Urine Variance analysis |
| title | Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A03%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolomic%20Study%20of%20Zuojin%20Pill%20in%20Relieving%201-Methyl-3-nitro-1-nitrosoguanidine-Induced%20Chronic%20Atrophic%20Gastritis&rft.jtitle=Evidence-based%20complementary%20and%20alternative%20medicine&rft.au=Tong,%20Yuling&rft.date=2021&rft.volume=2021&rft.spage=7004798&rft.epage=13&rft.pages=7004798-13&rft.issn=1741-427X&rft.eissn=1741-4288&rft_id=info:doi/10.1155/2021/7004798&rft_dat=%3Cproquest_pubme%3E2614758527%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2613962756&rft_id=info:pmid/34956382&rfr_iscdi=true |