Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies
Dietary fiber supplementation has been studied as a promising strategy in the treatment of obesity and its comorbidities. A systematic review and meta-analysis were performed to verify whether the consumption of yeast beta-glucan (BG) favors weight loss in obese and non-obese rodents. The PICO strat...
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| Veröffentlicht in: | Nutrients 2021-11, Vol.13 (12), p.4250 |
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| creator | Canaan, Marcelo M Reis-Canaan, Juliana C Zangerônimo, Márcio G Andrade, Eric F Gonçalves, Thais M S V Pereira, Michel C A Lima, Renato R Pardi, Vanessa Murata, Ramiro M Pereira, Luciano J |
| description | Dietary fiber supplementation has been studied as a promising strategy in the treatment of obesity and its comorbidities. A systematic review and meta-analysis were performed to verify whether the consumption of yeast beta-glucan (BG) favors weight loss in obese and non-obese rodents. The PICO strategy was employed, investigating rodents (Population), subjected to the oral administration of yeast BG (Intervention) compared to animals receiving placebo (Comparison), evaluating body weight changes (Outcome), and based on preclinical studies (Study design). Two reviewers searched six databases and the grey literature. We followed the PRISMA 2020 guidelines, and the protocol was registered on PROSPERO (CRD42021267788). The search returned 2467 articles. Thirty articles were selected for full-text evaluation, and seven studies remained based on the eligibility criteria. The effects of BG intake on body weight were analyzed based on obese (
= 4 studies) and non-obese animals (
= 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference -1.35 g-95% CI -5.14:2.45). No effects were also observed for non-obese animals. We concluded that the ingestion of yeast BG barely affects the body weight of obese and non-obese animals. |
| doi_str_mv | 10.3390/nu13124250 |
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= 4 studies) and non-obese animals (
= 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference -1.35 g-95% CI -5.14:2.45). No effects were also observed for non-obese animals. We concluded that the ingestion of yeast BG barely affects the body weight of obese and non-obese animals.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13124250</identifier><identifier>PMID: 34959802</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer's disease ; Animals ; beta-Glucans - pharmacology ; Bias ; Body weight ; Body Weight - drug effects ; Body weight loss ; Cancer ; Diabetes ; Eating - physiology ; Glucan ; Glucans ; Ingestion ; Laboratory animals ; Meta-analysis ; Metabolism ; Mice ; Obesity ; Obesity - metabolism ; Oral administration ; Overweight ; Qualitative analysis ; Rats ; Review ; Rodents ; Saccharomyces cerevisiae ; Software ; Systematic review ; Weight control ; Weight loss ; Weight Loss - drug effects ; Yeast ; Yeasts ; β-Glucan</subject><ispartof>Nutrients, 2021-11, Vol.13 (12), p.4250</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-4c2af4ba2c9e71af1cff0270758b6703950f0b73f1a4584bd201f43bf59837623</citedby><cites>FETCH-LOGICAL-c406t-4c2af4ba2c9e71af1cff0270758b6703950f0b73f1a4584bd201f43bf59837623</cites><orcidid>0000-0002-9253-3108 ; 0000-0002-8478-6981 ; 0000-0002-3404-0639 ; 0000-0002-0502-2554 ; 0000-0001-5618-1988 ; 0000-0002-3530-9345</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34959802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Canaan, Marcelo M</creatorcontrib><creatorcontrib>Reis-Canaan, Juliana C</creatorcontrib><creatorcontrib>Zangerônimo, Márcio G</creatorcontrib><creatorcontrib>Andrade, Eric F</creatorcontrib><creatorcontrib>Gonçalves, Thais M S V</creatorcontrib><creatorcontrib>Pereira, Michel C A</creatorcontrib><creatorcontrib>Lima, Renato R</creatorcontrib><creatorcontrib>Pardi, Vanessa</creatorcontrib><creatorcontrib>Murata, Ramiro M</creatorcontrib><creatorcontrib>Pereira, Luciano J</creatorcontrib><title>Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Dietary fiber supplementation has been studied as a promising strategy in the treatment of obesity and its comorbidities. A systematic review and meta-analysis were performed to verify whether the consumption of yeast beta-glucan (BG) favors weight loss in obese and non-obese rodents. The PICO strategy was employed, investigating rodents (Population), subjected to the oral administration of yeast BG (Intervention) compared to animals receiving placebo (Comparison), evaluating body weight changes (Outcome), and based on preclinical studies (Study design). Two reviewers searched six databases and the grey literature. We followed the PRISMA 2020 guidelines, and the protocol was registered on PROSPERO (CRD42021267788). The search returned 2467 articles. Thirty articles were selected for full-text evaluation, and seven studies remained based on the eligibility criteria. The effects of BG intake on body weight were analyzed based on obese (
= 4 studies) and non-obese animals (
= 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference -1.35 g-95% CI -5.14:2.45). No effects were also observed for non-obese animals. 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= 4 studies) and non-obese animals (
= 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference -1.35 g-95% CI -5.14:2.45). No effects were also observed for non-obese animals. We concluded that the ingestion of yeast BG barely affects the body weight of obese and non-obese animals.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34959802</pmid><doi>10.3390/nu13124250</doi><orcidid>https://orcid.org/0000-0002-9253-3108</orcidid><orcidid>https://orcid.org/0000-0002-8478-6981</orcidid><orcidid>https://orcid.org/0000-0002-3404-0639</orcidid><orcidid>https://orcid.org/0000-0002-0502-2554</orcidid><orcidid>https://orcid.org/0000-0001-5618-1988</orcidid><orcidid>https://orcid.org/0000-0002-3530-9345</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alzheimer's disease Animals beta-Glucans - pharmacology Bias Body weight Body Weight - drug effects Body weight loss Cancer Diabetes Eating - physiology Glucan Glucans Ingestion Laboratory animals Meta-analysis Metabolism Mice Obesity Obesity - metabolism Oral administration Overweight Qualitative analysis Rats Review Rodents Saccharomyces cerevisiae Software Systematic review Weight control Weight loss Weight Loss - drug effects Yeast Yeasts β-Glucan |
| title | Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies |
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