The Red Seaweed Grateloupia turuturu Prevents Epidermal Dysplasia in HPV16-Transgenic Mice
The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemoprevent...
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| Veröffentlicht in: | Nutrients 2021-12, Vol.13 (12), p.4529 |
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| creator | Almeida, José Ferreira, Tiago Santos, Susana Pires, Maria J da Costa, Rui M Gil Medeiros, Rui Bastos, Margarida M S M Neuparth, Maria J Faustino-Rocha, Ana I Abreu, Helena Pereira, Rui Pacheco, Mário Gaivão, Isabel Rosa, Eduardo Oliveira, Paula A |
| description | The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed
has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of
against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV
or HPV
mice received a standard diet or were supplemented with 10%
for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed.
consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed
edibility as no signs of toxicity were found. Dietary supplementation with
is an effective and safe chemopreventive strategy in this model. |
| doi_str_mv | 10.3390/nu13124529 |
| format | Article |
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has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of
against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV
or HPV
mice received a standard diet or were supplemented with 10%
for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed.
consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed
edibility as no signs of toxicity were found. Dietary supplementation with
is an effective and safe chemopreventive strategy in this model.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu13124529</identifier><identifier>PMID: 34960081</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Algae ; Animals ; Anticarcinogenic Agents ; Biocompatibility ; Biological Products ; Cancer ; Chromatography ; Deoxyribonucleic acid ; Diet ; Dietary Supplements ; DNA ; Dysplasia ; Fatty acids ; Female ; Food ; Functional foods & nutraceuticals ; Grateloupia turuturu ; Health care ; Histology ; Human papillomavirus ; Human papillomavirus 16 - genetics ; In vivo methods and tests ; Lesions ; Lipids ; Mice ; Mice, Transgenic ; Organs ; Papillomavirus Infections - virology ; Phytochemicals ; Phytotherapy ; Rhodophyta ; Risk reduction ; Seaweed ; Seaweeds ; Skin ; Skin Neoplasms ; Toxicity ; Transgenic mice</subject><ispartof>Nutrients, 2021-12, Vol.13 (12), p.4529</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-cde702de242ea85edc144990943c1bb8d7c2bbcd86369cbbf3c71e98bb378d803</citedby><cites>FETCH-LOGICAL-c406t-cde702de242ea85edc144990943c1bb8d7c2bbcd86369cbbf3c71e98bb378d803</cites><orcidid>0000-0001-9519-4044 ; 0000-0002-2151-2449 ; 0000-0002-8605-0054 ; 0000-0003-0552-9643 ; 0000-0003-4461-7021 ; 0000-0002-6652-9770</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707361/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707361/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34960081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida, José</creatorcontrib><creatorcontrib>Ferreira, Tiago</creatorcontrib><creatorcontrib>Santos, Susana</creatorcontrib><creatorcontrib>Pires, Maria J</creatorcontrib><creatorcontrib>da Costa, Rui M Gil</creatorcontrib><creatorcontrib>Medeiros, Rui</creatorcontrib><creatorcontrib>Bastos, Margarida M S M</creatorcontrib><creatorcontrib>Neuparth, Maria J</creatorcontrib><creatorcontrib>Faustino-Rocha, Ana I</creatorcontrib><creatorcontrib>Abreu, Helena</creatorcontrib><creatorcontrib>Pereira, Rui</creatorcontrib><creatorcontrib>Pacheco, Mário</creatorcontrib><creatorcontrib>Gaivão, Isabel</creatorcontrib><creatorcontrib>Rosa, Eduardo</creatorcontrib><creatorcontrib>Oliveira, Paula A</creatorcontrib><title>The Red Seaweed Grateloupia turuturu Prevents Epidermal Dysplasia in HPV16-Transgenic Mice</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed
has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of
against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV
or HPV
mice received a standard diet or were supplemented with 10%
for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed.
consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed
edibility as no signs of toxicity were found. Dietary supplementation with
is an effective and safe chemopreventive strategy in this model.</description><subject>Algae</subject><subject>Animals</subject><subject>Anticarcinogenic Agents</subject><subject>Biocompatibility</subject><subject>Biological Products</subject><subject>Cancer</subject><subject>Chromatography</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>DNA</subject><subject>Dysplasia</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food</subject><subject>Functional foods & nutraceuticals</subject><subject>Grateloupia turuturu</subject><subject>Health care</subject><subject>Histology</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16 - genetics</subject><subject>In vivo methods and tests</subject><subject>Lesions</subject><subject>Lipids</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Organs</subject><subject>Papillomavirus Infections - 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Red Seaweed Grateloupia turuturu Prevents Epidermal Dysplasia in HPV16-Transgenic Mice</title><author>Almeida, José ; Ferreira, Tiago ; Santos, Susana ; Pires, Maria J ; da Costa, Rui M Gil ; Medeiros, Rui ; Bastos, Margarida M S M ; Neuparth, Maria J ; Faustino-Rocha, Ana I ; Abreu, Helena ; Pereira, Rui ; Pacheco, Mário ; Gaivão, Isabel ; Rosa, Eduardo ; Oliveira, Paula A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-cde702de242ea85edc144990943c1bb8d7c2bbcd86369cbbf3c71e98bb378d803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Algae</topic><topic>Animals</topic><topic>Anticarcinogenic Agents</topic><topic>Biocompatibility</topic><topic>Biological Products</topic><topic>Cancer</topic><topic>Chromatography</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>DNA</topic><topic>Dysplasia</topic><topic>Fatty 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Mice</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2021-12-17</date><risdate>2021</risdate><volume>13</volume><issue>12</issue><spage>4529</spage><pages>4529-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed
has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of
against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV
or HPV
mice received a standard diet or were supplemented with 10%
for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed.
consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed
edibility as no signs of toxicity were found. Dietary supplementation with
is an effective and safe chemopreventive strategy in this model.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34960081</pmid><doi>10.3390/nu13124529</doi><orcidid>https://orcid.org/0000-0001-9519-4044</orcidid><orcidid>https://orcid.org/0000-0002-2151-2449</orcidid><orcidid>https://orcid.org/0000-0002-8605-0054</orcidid><orcidid>https://orcid.org/0000-0003-0552-9643</orcidid><orcidid>https://orcid.org/0000-0003-4461-7021</orcidid><orcidid>https://orcid.org/0000-0002-6652-9770</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2021-12, Vol.13 (12), p.4529 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Algae Animals Anticarcinogenic Agents Biocompatibility Biological Products Cancer Chromatography Deoxyribonucleic acid Diet Dietary Supplements DNA Dysplasia Fatty acids Female Food Functional foods & nutraceuticals Grateloupia turuturu Health care Histology Human papillomavirus Human papillomavirus 16 - genetics In vivo methods and tests Lesions Lipids Mice Mice, Transgenic Organs Papillomavirus Infections - virology Phytochemicals Phytotherapy Rhodophyta Risk reduction Seaweed Seaweeds Skin Skin Neoplasms Toxicity Transgenic mice |
| title | The Red Seaweed Grateloupia turuturu Prevents Epidermal Dysplasia in HPV16-Transgenic Mice |
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