Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene

Dysfunctions in the endo-lysosomal system have been hypothesized to underlie neurodegeneration in major neurocognitive disorders due to Alzheimer's disease (AD), Frontotemporal Lobar Degeneration (FTLD), and Lewy body disease (DLB). The aim of this study is to investigate whether these diseases...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.22 (24), p.13633
Hauptverfasser:	Benussi, Luisa, Longobardi, Antonio, Kocoglu, Cemile, Carrara, Matteo, Bellini, Sonia, Ferrari, Clarissa, Nicsanu, Roland, Saraceno, Claudia, Bonvicini, Cristian, Fostinelli, Silvia, Zanardini, Roberta, Catania, Marcella, Moisse, Matthieu, Van Damme, Philip, Di Fede, Giuseppe, Binetti, Giuliano, Van Broeckhoven, Christine, van der Zee, Julie, Ghidoni, Roberta
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Clathrin Cognition Degeneration Enzymatic activity Etiology Family medical history Female Frontotemporal dementia Frontotemporal Lobar Degeneration - genetics Frontotemporal Lobar Degeneration - metabolism Genes Genetic analysis Genetic Predisposition to Disease Genetic variability Genetics Health risk assessment High-Throughput Nucleotide Sequencing HSP40 Heat-Shock Proteins - genetics Humans LDL-Receptor Related Proteins - genetics Lewy bodies Lewy body disease Lewy Body Disease - genetics Lewy Body Disease - metabolism Lysosomes - metabolism Male Membrane Transport Proteins - genetics Middle Aged Mutation Neurodegeneration Parkinson's disease Pathogenesis Patients Polymorphism, Single Nucleotide Protein transport Proteins Sequence Analysis, DNA Uncoating
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!