Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice

Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space ra...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.22 (24), p.13305
Hauptverfasser:	Schroeder, Maren K., Liu, Bin, Hinshaw, Robert G., Park, Mi-Ae, Wang, Shuyan, Dubey, Shipra, Liu, Grace Geyu, Shi, Qiaoqiao, Holton, Peter, Reiser, Vladimir, Jones, Paul A., Trigg, William, Di Carli, Marcelo F., Caldarone, Barbara J., Williams, Jacqueline P., O’Banion, M. Kerry, Lemere, Cynthia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerospace medicine Alzheimer's disease Astronauts Behavior Beta rays Extraterrestrial radiation Females Gamma rays Genotype & phenotype Genotypes Gliosis Health risk assessment Inflammation Iron isotopes Males Manned space flight Mars Memory Memory tasks Motor ability Mutation Neurogenesis Pathology Presenilin 1 Radiation Radiation effects Rodents Space flight Spatial analysis Spatial memory Transgenic animals Transgenic mice
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