Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior
Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2021-12, Vol.22 (24), p.13516 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 24 |
| container_start_page | 13516 |
| container_title | International journal of molecular sciences |
| container_volume | 22 |
| creator | Liu, Jiayue Tian, Bingren Liu, Yumei Wan, Jian-Bo |
| description | Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented. |
| doi_str_mv | 10.3390/ijms222413516 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8703588</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2612813663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-700cf69728700a75f06711984bdbc7fd55a54d1039790f877792ee8372ebf81c3</originalsourceid><addsrcrecordid>eNpdkctP3DAQxi3Uivex18oSlx5I60ccOxwq0QVKJRAIwdnyxpOsV1l7aycL-99jtBRBTzOj-embx4fQF0q-c16TH26-SIyxknJBqy20S0vGCkIq-eldvoP2UpoTwjgT9Tba4WVdKk7ZLppP1k0fLDwN0fliEvxgnHe-w5drG0MHfTrBp_gOVg4ecWjxbYSliWZwweNrGGbBHuOzOHb4DHq3grg-xsbbXHXR2A32C2Zm5UI8QJ9b0yc4fI376OHi_H5yWVzd_P4zOb0qmpKKoZCENG1VS6ZyZqRo8_6U1qqc2mkjWyuEEaWlhNeyJq2SUtYMQHHJYNoq2vB99HOjuxynC7AN-CGaXi-jW5i41sE4_bHj3Ux3YaXzQC6UygLfXgVi-DtCGvTCpQb63ngIY9Ksyo_lipQio0f_ofMwRp_Pe6GYoryqeKaKDdXEkFKE9m0ZSvSLi_qDi5n_-v6CN_qfbfwZ9JaYhQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2612813663</pqid></control><display><type>article</type><title>Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior</title><source>PubMed (Medline)</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Liu, Jiayue ; Tian, Bingren ; Liu, Yumei ; Wan, Jian-Bo</creator><creatorcontrib>Liu, Jiayue ; Tian, Bingren ; Liu, Yumei ; Wan, Jian-Bo</creatorcontrib><description>Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms222413516</identifier><identifier>PMID: 34948312</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Biomedical materials ; Cellulose ; Chemical bonds ; Cyclodextrin ; Cyclodextrins ; Cyclodextrins - chemistry ; Diabetes ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drugs ; Efficiency ; Humans ; Hydrogels ; Hydrogels - chemistry ; Insulin ; Oligosaccharides ; Oligosaccharides - chemistry ; Polymerization ; Review</subject><ispartof>International journal of molecular sciences, 2021-12, Vol.22 (24), p.13516</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-700cf69728700a75f06711984bdbc7fd55a54d1039790f877792ee8372ebf81c3</citedby><cites>FETCH-LOGICAL-c415t-700cf69728700a75f06711984bdbc7fd55a54d1039790f877792ee8372ebf81c3</cites><orcidid>0000-0001-7022-2467 ; 0000-0001-9535-129X ; 0000-0002-6750-2617 ; 0000-0003-0853-8158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703588/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703588/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34948312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jiayue</creatorcontrib><creatorcontrib>Tian, Bingren</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Wan, Jian-Bo</creatorcontrib><title>Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.</description><subject>Animals</subject><subject>Biomedical materials</subject><subject>Cellulose</subject><subject>Chemical bonds</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Cyclodextrins - chemistry</subject><subject>Diabetes</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Drugs</subject><subject>Efficiency</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Insulin</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - chemistry</subject><subject>Polymerization</subject><subject>Review</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctP3DAQxi3Uivex18oSlx5I60ccOxwq0QVKJRAIwdnyxpOsV1l7aycL-99jtBRBTzOj-embx4fQF0q-c16TH26-SIyxknJBqy20S0vGCkIq-eldvoP2UpoTwjgT9Tba4WVdKk7ZLppP1k0fLDwN0fliEvxgnHe-w5drG0MHfTrBp_gOVg4ecWjxbYSliWZwweNrGGbBHuOzOHb4DHq3grg-xsbbXHXR2A32C2Zm5UI8QJ9b0yc4fI376OHi_H5yWVzd_P4zOb0qmpKKoZCENG1VS6ZyZqRo8_6U1qqc2mkjWyuEEaWlhNeyJq2SUtYMQHHJYNoq2vB99HOjuxynC7AN-CGaXi-jW5i41sE4_bHj3Ux3YaXzQC6UygLfXgVi-DtCGvTCpQb63ngIY9Ksyo_lipQio0f_ofMwRp_Pe6GYoryqeKaKDdXEkFKE9m0ZSvSLi_qDi5n_-v6CN_qfbfwZ9JaYhQ</recordid><startdate>20211216</startdate><enddate>20211216</enddate><creator>Liu, Jiayue</creator><creator>Tian, Bingren</creator><creator>Liu, Yumei</creator><creator>Wan, Jian-Bo</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7022-2467</orcidid><orcidid>https://orcid.org/0000-0001-9535-129X</orcidid><orcidid>https://orcid.org/0000-0002-6750-2617</orcidid><orcidid>https://orcid.org/0000-0003-0853-8158</orcidid></search><sort><creationdate>20211216</creationdate><title>Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior</title><author>Liu, Jiayue ; Tian, Bingren ; Liu, Yumei ; Wan, Jian-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-700cf69728700a75f06711984bdbc7fd55a54d1039790f877792ee8372ebf81c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biomedical materials</topic><topic>Cellulose</topic><topic>Chemical bonds</topic><topic>Cyclodextrin</topic><topic>Cyclodextrins</topic><topic>Cyclodextrins - chemistry</topic><topic>Diabetes</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Drugs</topic><topic>Efficiency</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Insulin</topic><topic>Oligosaccharides</topic><topic>Oligosaccharides - chemistry</topic><topic>Polymerization</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jiayue</creatorcontrib><creatorcontrib>Tian, Bingren</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Wan, Jian-Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Proquest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jiayue</au><au>Tian, Bingren</au><au>Liu, Yumei</au><au>Wan, Jian-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-12-16</date><risdate>2021</risdate><volume>22</volume><issue>24</issue><spage>13516</spage><pages>13516-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Hydrogels possess porous structures, which are widely applied in the field of materials and biomedicine. As a natural oligosaccharide, cyclodextrin (CD) has shown remarkable application prospects in the synthesis and utilization of hydrogels. CD can be incorporated into hydrogels to form chemically or physically cross-linked networks. Furthermore, the unique cavity structure of CD makes it an ideal vehicle for the delivery of active ingredients into target tissues. This review describes useful methods to prepare CD-containing hydrogels. In addition, the potential biomedical applications of CD-containing hydrogels are reviewed. The release and degradation process of CD-containing hydrogels under different conditions are discussed. Finally, the current challenges and future research directions on CD-containing hydrogels are presented.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34948312</pmid><doi>10.3390/ijms222413516</doi><orcidid>https://orcid.org/0000-0001-7022-2467</orcidid><orcidid>https://orcid.org/0000-0001-9535-129X</orcidid><orcidid>https://orcid.org/0000-0002-6750-2617</orcidid><orcidid>https://orcid.org/0000-0003-0853-8158</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-12, Vol.22 (24), p.13516 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8703588 |
| source | PubMed (Medline); MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB Electronic Journals Library |
| subjects | Animals Biomedical materials Cellulose Chemical bonds Cyclodextrin Cyclodextrins Cyclodextrins - chemistry Diabetes Drug delivery Drug delivery systems Drug Delivery Systems - methods Drugs Efficiency Humans Hydrogels Hydrogels - chemistry Insulin Oligosaccharides Oligosaccharides - chemistry Polymerization Review |
| title | Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T21%3A59%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cyclodextrin-Containing%20Hydrogels:%20A%20Review%20of%20Preparation%20Method,%20Drug%20Delivery,%20and%20Degradation%20Behavior&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Liu,%20Jiayue&rft.date=2021-12-16&rft.volume=22&rft.issue=24&rft.spage=13516&rft.pages=13516-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms222413516&rft_dat=%3Cproquest_pubme%3E2612813663%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2612813663&rft_id=info:pmid/34948312&rfr_iscdi=true |