Postoperative hypoalbuminemia is an independent predictor of 1-year mortality after surgery for geriatric intertrochanteric femoral fracture: A retrospective cohort study
Preoperative hypoalbuminemia from malnutrition is associated with increased morbidity and mortality after geriatric hip fracture surgery. However, little is known regarding the correlation between postoperative hypoalbuminemia and mortality. This study aimed to evaluate whether postoperative hypoalb...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-12, Vol.100 (51), p.e28306-e28306 |
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| creator | Choi, Sung Uk Rho, Jeong Ho Choi, Yoon Ji Jun, Seung Woo Shin, Young Jae Lee, Yoon Sook Shin, Hyeon Ju Lim, Choon Hak Shin, Hye Won Kim, Jae Hwan Lee, Hye Won Lim, Hye Ja |
| description | Preoperative hypoalbuminemia from malnutrition is associated with increased morbidity and mortality after geriatric hip fracture surgery. However, little is known regarding the correlation between postoperative hypoalbuminemia and mortality. This study aimed to evaluate whether postoperative hypoalbuminemia could predict 1-year mortality after intertrochanteric femoral fracture surgery in elderly patients.The medical records of 263 geriatric patients (age ≥65 years) who underwent intertrochanteric femoral fracture surgery between January 2013 and January 2016 in a single hospital were reviewed retrospectively. The patients were allocated to 2 groups based on lowest serum albumin levels within 2 postoperative days (≥3.0 g/dL [group 1, n = 46] and |
| doi_str_mv | 10.1097/MD.0000000000028306 |
| format | Article |
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However, little is known regarding the correlation between postoperative hypoalbuminemia and mortality. This study aimed to evaluate whether postoperative hypoalbuminemia could predict 1-year mortality after intertrochanteric femoral fracture surgery in elderly patients.The medical records of 263 geriatric patients (age ≥65 years) who underwent intertrochanteric femoral fracture surgery between January 2013 and January 2016 in a single hospital were reviewed retrospectively. The patients were allocated to 2 groups based on lowest serum albumin levels within 2 postoperative days (≥3.0 g/dL [group 1, n = 46] and <3.0 g/dL [group 2, n = 217]. Data between the non-survival and survival groups were compared. Multivariable logistic regression analysis was conducted to identify the independent predictor for 1-year mortality.The 1-year mortality rate was 16.3% after intertrochanteric femoral fracture surgery. Multivariable logistic regression analysis revealed that postoperative hypoalbuminemia was significantly associated with 1-year mortality (adjusted odds ratio, 8.03; 95% confidence interval, 1.37-47.09; P = .021). The non-survival group showed a significantly increased incidence of postoperative hypoalbuminemia (95.4% vs 80.0%, P = .015) and intensive care unit admission (11.6% vs 2.7%, P = .020), older age (82.5 ± 5.8 years vs 80.0 ± 7.2 years, P = .032), lower body mass index (20.1 ± 3.2 kg/m2 vs 22.4 ± 3.8 kg/m2, P < .001), and increased amount of transfusion of perioperative red blood cells (1.79 ± 1.47 units vs 1.43 ± 2.08 units, P = .032), compared to the survival group.This study demonstrated that postoperative hypoalbuminemia is a potent predictor of 1-year mortality in geriatric patients undergoing intertrochanteric femoral fracture surgery. Therefore, exogenous albumin administration can be considered to improve postoperative outcomes and reduce the risk of mortality after surgery for geriatric hip fracture.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000028306</identifier><identifier>PMID: 34941120</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Female ; Hip Fractures - mortality ; Hip Fractures - surgery ; Humans ; Hypoalbuminemia - complications ; Incidence ; Male ; Observational Study ; Postoperative Complications ; Retrospective Studies ; Risk Factors ; Serum Albumin</subject><ispartof>Medicine (Baltimore), 2021-12, Vol.100 (51), p.e28306-e28306</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3556-1e98d19f88c103d3f34f5ca2450a2d69696415ef2abd6fa216889b1cd80468f83</cites><orcidid>0000-0003-3150-6840</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701452/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701452/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34941120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Sung Uk</creatorcontrib><creatorcontrib>Rho, Jeong Ho</creatorcontrib><creatorcontrib>Choi, Yoon Ji</creatorcontrib><creatorcontrib>Jun, Seung Woo</creatorcontrib><creatorcontrib>Shin, Young Jae</creatorcontrib><creatorcontrib>Lee, Yoon Sook</creatorcontrib><creatorcontrib>Shin, Hyeon Ju</creatorcontrib><creatorcontrib>Lim, Choon Hak</creatorcontrib><creatorcontrib>Shin, Hye Won</creatorcontrib><creatorcontrib>Kim, Jae Hwan</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Lim, Hye Ja</creatorcontrib><title>Postoperative hypoalbuminemia is an independent predictor of 1-year mortality after surgery for geriatric intertrochanteric femoral fracture: A retrospective cohort study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Preoperative hypoalbuminemia from malnutrition is associated with increased morbidity and mortality after geriatric hip fracture surgery. However, little is known regarding the correlation between postoperative hypoalbuminemia and mortality. This study aimed to evaluate whether postoperative hypoalbuminemia could predict 1-year mortality after intertrochanteric femoral fracture surgery in elderly patients.The medical records of 263 geriatric patients (age ≥65 years) who underwent intertrochanteric femoral fracture surgery between January 2013 and January 2016 in a single hospital were reviewed retrospectively. The patients were allocated to 2 groups based on lowest serum albumin levels within 2 postoperative days (≥3.0 g/dL [group 1, n = 46] and <3.0 g/dL [group 2, n = 217]. Data between the non-survival and survival groups were compared. Multivariable logistic regression analysis was conducted to identify the independent predictor for 1-year mortality.The 1-year mortality rate was 16.3% after intertrochanteric femoral fracture surgery. Multivariable logistic regression analysis revealed that postoperative hypoalbuminemia was significantly associated with 1-year mortality (adjusted odds ratio, 8.03; 95% confidence interval, 1.37-47.09; P = .021). The non-survival group showed a significantly increased incidence of postoperative hypoalbuminemia (95.4% vs 80.0%, P = .015) and intensive care unit admission (11.6% vs 2.7%, P = .020), older age (82.5 ± 5.8 years vs 80.0 ± 7.2 years, P = .032), lower body mass index (20.1 ± 3.2 kg/m2 vs 22.4 ± 3.8 kg/m2, P < .001), and increased amount of transfusion of perioperative red blood cells (1.79 ± 1.47 units vs 1.43 ± 2.08 units, P = .032), compared to the survival group.This study demonstrated that postoperative hypoalbuminemia is a potent predictor of 1-year mortality in geriatric patients undergoing intertrochanteric femoral fracture surgery. Therefore, exogenous albumin administration can be considered to improve postoperative outcomes and reduce the risk of mortality after surgery for geriatric hip fracture.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Hip Fractures - mortality</subject><subject>Hip Fractures - surgery</subject><subject>Humans</subject><subject>Hypoalbuminemia - complications</subject><subject>Incidence</subject><subject>Male</subject><subject>Observational Study</subject><subject>Postoperative Complications</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Serum Albumin</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctu1TAQhiMEoqXwBEjISzYpvsWJWSBVLTepFSxgbfk448aQxMF2WuWVeEqmPaVcbMkezXzze8ZTVc8ZPWZUt68uzo7pn8U7QdWD6pA1QtWNVvJhdYjepm51Kw-qJzl_o5SJlsvH1YGQWjLG6WH183PMJS6QbAlXQIZtiXbcrVOYYQqWhEzsTMLcwwJ4zIUsCfrgSkwkesLqDWwiU0zFjqFsxPoCieQ1XULaiEcKjWBLCg5VMFZSdIO9sdDjATPtSHyyrqwJXpMTkgCRvIC7rcfFAbVJLmu_Pa0eeTtmeHZ3H1Vf3739cvqhPv_0_uPpyXntRNOomoHueqZ91zlGRS-8kL5xlsuGWt4rjVuyBjy3u155y5nqOr1jru-oVJ3vxFH1Zq-7rLsJeoddY5FmSWGyaTPRBvNvZA6DuYxXpmspkw1HgZd3Ain-WCEXM4XsYBztDHHNhismOddcUUTFHnXYdE7g759h1NxM2Vycmf-njFkv_q7wPuf3WBGQe-A6jvjV-fu4XkMyA9ixDLd6Tat5zSlHnAtao0cr8QveH7hG</recordid><startdate>20211223</startdate><enddate>20211223</enddate><creator>Choi, Sung Uk</creator><creator>Rho, Jeong Ho</creator><creator>Choi, Yoon Ji</creator><creator>Jun, Seung Woo</creator><creator>Shin, Young Jae</creator><creator>Lee, Yoon Sook</creator><creator>Shin, Hyeon Ju</creator><creator>Lim, Choon Hak</creator><creator>Shin, Hye Won</creator><creator>Kim, Jae Hwan</creator><creator>Lee, Hye Won</creator><creator>Lim, Hye Ja</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3150-6840</orcidid></search><sort><creationdate>20211223</creationdate><title>Postoperative hypoalbuminemia is an independent predictor of 1-year mortality after surgery for geriatric intertrochanteric femoral fracture: A retrospective cohort study</title><author>Choi, Sung Uk ; Rho, Jeong Ho ; Choi, Yoon Ji ; Jun, Seung Woo ; Shin, Young Jae ; Lee, Yoon Sook ; Shin, Hyeon Ju ; Lim, Choon Hak ; Shin, Hye Won ; Kim, Jae Hwan ; Lee, Hye Won ; Lim, Hye Ja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3556-1e98d19f88c103d3f34f5ca2450a2d69696415ef2abd6fa216889b1cd80468f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Hip Fractures - mortality</topic><topic>Hip Fractures - surgery</topic><topic>Humans</topic><topic>Hypoalbuminemia - complications</topic><topic>Incidence</topic><topic>Male</topic><topic>Observational Study</topic><topic>Postoperative Complications</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Serum Albumin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Sung Uk</creatorcontrib><creatorcontrib>Rho, Jeong Ho</creatorcontrib><creatorcontrib>Choi, Yoon Ji</creatorcontrib><creatorcontrib>Jun, Seung Woo</creatorcontrib><creatorcontrib>Shin, Young Jae</creatorcontrib><creatorcontrib>Lee, Yoon Sook</creatorcontrib><creatorcontrib>Shin, Hyeon Ju</creatorcontrib><creatorcontrib>Lim, Choon Hak</creatorcontrib><creatorcontrib>Shin, Hye Won</creatorcontrib><creatorcontrib>Kim, Jae Hwan</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Lim, Hye Ja</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Sung Uk</au><au>Rho, Jeong Ho</au><au>Choi, Yoon Ji</au><au>Jun, Seung Woo</au><au>Shin, Young Jae</au><au>Lee, Yoon Sook</au><au>Shin, Hyeon Ju</au><au>Lim, Choon Hak</au><au>Shin, Hye Won</au><au>Kim, Jae Hwan</au><au>Lee, Hye Won</au><au>Lim, Hye Ja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative hypoalbuminemia is an independent predictor of 1-year mortality after surgery for geriatric intertrochanteric femoral fracture: A retrospective cohort study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-12-23</date><risdate>2021</risdate><volume>100</volume><issue>51</issue><spage>e28306</spage><epage>e28306</epage><pages>e28306-e28306</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Preoperative hypoalbuminemia from malnutrition is associated with increased morbidity and mortality after geriatric hip fracture surgery. However, little is known regarding the correlation between postoperative hypoalbuminemia and mortality. This study aimed to evaluate whether postoperative hypoalbuminemia could predict 1-year mortality after intertrochanteric femoral fracture surgery in elderly patients.The medical records of 263 geriatric patients (age ≥65 years) who underwent intertrochanteric femoral fracture surgery between January 2013 and January 2016 in a single hospital were reviewed retrospectively. The patients were allocated to 2 groups based on lowest serum albumin levels within 2 postoperative days (≥3.0 g/dL [group 1, n = 46] and <3.0 g/dL [group 2, n = 217]. Data between the non-survival and survival groups were compared. Multivariable logistic regression analysis was conducted to identify the independent predictor for 1-year mortality.The 1-year mortality rate was 16.3% after intertrochanteric femoral fracture surgery. Multivariable logistic regression analysis revealed that postoperative hypoalbuminemia was significantly associated with 1-year mortality (adjusted odds ratio, 8.03; 95% confidence interval, 1.37-47.09; P = .021). The non-survival group showed a significantly increased incidence of postoperative hypoalbuminemia (95.4% vs 80.0%, P = .015) and intensive care unit admission (11.6% vs 2.7%, P = .020), older age (82.5 ± 5.8 years vs 80.0 ± 7.2 years, P = .032), lower body mass index (20.1 ± 3.2 kg/m2 vs 22.4 ± 3.8 kg/m2, P < .001), and increased amount of transfusion of perioperative red blood cells (1.79 ± 1.47 units vs 1.43 ± 2.08 units, P = .032), compared to the survival group.This study demonstrated that postoperative hypoalbuminemia is a potent predictor of 1-year mortality in geriatric patients undergoing intertrochanteric femoral fracture surgery. Therefore, exogenous albumin administration can be considered to improve postoperative outcomes and reduce the risk of mortality after surgery for geriatric hip fracture.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34941120</pmid><doi>10.1097/MD.0000000000028306</doi><orcidid>https://orcid.org/0000-0003-3150-6840</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Female Hip Fractures - mortality Hip Fractures - surgery Humans Hypoalbuminemia - complications Incidence Male Observational Study Postoperative Complications Retrospective Studies Risk Factors Serum Albumin |
| title | Postoperative hypoalbuminemia is an independent predictor of 1-year mortality after surgery for geriatric intertrochanteric femoral fracture: A retrospective cohort study |
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