UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissue samples to find possible correlation between the...

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Veröffentlicht in:	Genes 2021-12, Vol.12 (12), p.1978
Hauptverfasser:	Corrà, Fabio, Crudele, Francesca, Baldassari, Federica, Bianchi, Nicoletta, Galasso, Marco, Minotti, Linda, Agnoletto, Chiara, Di Leva, Gianpiero, Brugnoli, Federica, Reali, Eva, Bertagnolo, Valeria, Vecchione, Andrea, Volinia, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Cycle Cell Proliferation Conserved Sequence Data mining Datasets DNA methylation Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genomes Humans MicroRNAs MicroRNAs - genetics miRNA Nucleotide sequence Phenotypes RNA, Untranslated - genetics siRNA Software Tumor cell lines Tumor Cells, Cultured
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