Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS
Long non-coding RNAs (lncRNAs) are emerging as key players in a variety of cellular processes. Deregulation of the lncRNAs has been implicated in prostate and breast cancers. Recently, germline genetic variations associated with cancer risk have been correlated with lncRNA expression and/or function...
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| Veröffentlicht in: | Genes 2021-12, Vol.12 (12), p.2028 |
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| creator | Janaththani, Panchadsaram Srinivasan, Sri Lakshmi Batra, Jyotsna |
| description | Long non-coding RNAs (lncRNAs) are emerging as key players in a variety of cellular processes. Deregulation of the lncRNAs has been implicated in prostate and breast cancers. Recently, germline genetic variations associated with cancer risk have been correlated with lncRNA expression and/or function. In addition, single nucleotide polymorphisms (SNPs) at well-characterized cancer-associated lncRNAs have been analyzed for their association with cancer risk. These SNPs may occur within the lncRNA transcripts or spanning regions that may alter the structure, function, and expression of these lncRNA molecules and contribute to cancer progression and may have potential as therapeutic targets for cancer treatment. Additionally, some of these lncRNA have a tissue-specific expression profile, suggesting them as biomarkers for specific cancers. In this review, we highlight some of the cancer risk-associated SNPs that modulated lncRNAs with a potential role in prostate and breast cancers and speculate on how these lncRNAs may contribute to cancer development. |
| doi_str_mv | 10.3390/genes12122028 |
| format | Article |
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Deregulation of the lncRNAs has been implicated in prostate and breast cancers. Recently, germline genetic variations associated with cancer risk have been correlated with lncRNA expression and/or function. In addition, single nucleotide polymorphisms (SNPs) at well-characterized cancer-associated lncRNAs have been analyzed for their association with cancer risk. These SNPs may occur within the lncRNA transcripts or spanning regions that may alter the structure, function, and expression of these lncRNA molecules and contribute to cancer progression and may have potential as therapeutic targets for cancer treatment. Additionally, some of these lncRNA have a tissue-specific expression profile, suggesting them as biomarkers for specific cancers. In this review, we highlight some of the cancer risk-associated SNPs that modulated lncRNAs with a potential role in prostate and breast cancers and speculate on how these lncRNAs may contribute to cancer development.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes12122028</identifier><identifier>PMID: 34946977</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Androgens ; Breast cancer ; Breast Neoplasms - genetics ; Cell growth ; Disease ; Female ; Gene expression ; Genetic diversity ; Genetic Predisposition to Disease ; Genomes ; Health risk assessment ; Humans ; Male ; Non-coding RNA ; Organ Specificity ; Prostate cancer ; Prostatic Neoplasms - genetics ; Proteins ; Review ; RNA polymerase ; RNA, Long Noncoding - genetics ; Single-nucleotide polymorphism ; Structure-function relationships ; Therapeutic targets</subject><ispartof>Genes, 2021-12, Vol.12 (12), p.2028</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Srinivasan, Sri Lakshmi ; Batra, Jyotsna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-5717f9017aa636dbf7a372cc1dd85161c3f9ec63a86ece99757e7358f3be92f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Androgens</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Cell growth</topic><topic>Disease</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Non-coding RNA</topic><topic>Organ Specificity</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Proteins</topic><topic>Review</topic><topic>RNA polymerase</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Single-nucleotide polymorphism</topic><topic>Structure-function relationships</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janaththani, Panchadsaram</creatorcontrib><creatorcontrib>Srinivasan, Sri Lakshmi</creatorcontrib><creatorcontrib>Batra, Jyotsna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janaththani, Panchadsaram</au><au>Srinivasan, Sri Lakshmi</au><au>Batra, Jyotsna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2021-12-20</date><risdate>2021</risdate><volume>12</volume><issue>12</issue><spage>2028</spage><pages>2028-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>Long non-coding RNAs (lncRNAs) are emerging as key players in a variety of cellular processes. Deregulation of the lncRNAs has been implicated in prostate and breast cancers. Recently, germline genetic variations associated with cancer risk have been correlated with lncRNA expression and/or function. In addition, single nucleotide polymorphisms (SNPs) at well-characterized cancer-associated lncRNAs have been analyzed for their association with cancer risk. These SNPs may occur within the lncRNA transcripts or spanning regions that may alter the structure, function, and expression of these lncRNA molecules and contribute to cancer progression and may have potential as therapeutic targets for cancer treatment. Additionally, some of these lncRNA have a tissue-specific expression profile, suggesting them as biomarkers for specific cancers. 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| subjects | Androgens Breast cancer Breast Neoplasms - genetics Cell growth Disease Female Gene expression Genetic diversity Genetic Predisposition to Disease Genomes Health risk assessment Humans Male Non-coding RNA Organ Specificity Prostate cancer Prostatic Neoplasms - genetics Proteins Review RNA polymerase RNA, Long Noncoding - genetics Single-nucleotide polymorphism Structure-function relationships Therapeutic targets |
| title | Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS |
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