Immune Milieu and Genomic Alterations Set the Triple-Negative Breast Cancer Immunomodulatory Subtype Tumor Behavior

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Seven subtypes have been described based on gene expression patterns. Herein, we characterized the tumor biology and clinical behavior of the immunomodulatory (IM) subtype. Formalin-fixed paraffin-embedded tumor samples...

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Veröffentlicht in:	Cancers 2021-12, Vol.13 (24), p.6256
Hauptverfasser:	Rodríguez-Bautista, Rubén, Caro-Sánchez, Claudia H, Cabrera-Galeana, Paula, Alanis-Funes, Gerardo J, Gutierrez-Millán, Everardo, Ávila-Ríos, Santiago, Matías-Florentino, Margarita, Reyes-Terán, Gustavo, Díaz-Chávez, José, Villarreal-Garza, Cynthia, Hernández-Pedro, Norma Y, Ortega-Gómez, Alette, Lara-Mejía, Luis, Rangel-Escareño, Claudia, Arrieta, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Androgen receptors Antigens Breast cancer Cancer therapies Chemotherapy Clinical trials Cloning CTLA-4 protein DNA microarrays DNA sequencing Estrogens Foxp3 protein Gene expression Gene set enrichment analysis Genomics Immune response Immune system Immunohistochemistry Immunomodulation Immunotherapy Infiltration Lymphocytes Lymphocytes T Medical prognosis Mesenchyme Metastases Microenvironments Mutation Mutation rates Paraffin Patients PD-L1 protein Signal transduction Tumors β-Catenin
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