Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2021-11, Vol.10 (12), p.3357
Hauptverfasser:	Dubis, Joanna, Niepiekło-Miniewska, Wanda, Jędruchniewicz, Natalia, Sobczyński, Maciej, Witkiewicz, Wojciech, Zapotoczny, Norbert, Kuśnierczyk, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen abdominal aortic aneurism Adult Aged Aged, 80 and over aneurysm diameter Antigens Aorta Aortic Aneurysm, Abdominal - genetics Aortic aneurysms Body Mass Index Cardiovascular disease Case-Control Studies Cell surface Coronary Artery Disease - genetics Coronary vessels Cytokines Cytotoxicity Drug therapy Extracellular matrix Female Gene expression Gene frequency Generalized linear models Genetic analysis Genetic Association Studies Genetic diversity Genetic Predisposition to Disease genetics Genomes Genotyping Haplotypes - genetics Histocompatibility antigen HLA HLA HLA Antigens - genetics HLA Antigens - metabolism Humans immune cells Immune system Immunoglobulin-like receptors Immunoglobulins Inflammation Killer cell immunoglobulin-like receptors KIR Ligands Male Middle Aged Monte Carlo simulation Multivariate analysis Natural killer cells Pathogenesis Patients Polymerase chain reaction Potassium channels (inwardly-rectifying) R&D Receptors, KIR - genetics Receptors, KIR - metabolism Research & development
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