Alzheimer's Disease: Current Perspectives and Advances in Physiological Modeling

Though Alzheimer's disease (AD) is the most common cause of dementia, complete disease-modifying treatments are yet to be fully attained. Until recently, transgenic mice constituted most in vitro model systems of AD used for preclinical drug screening; however, these models have so far failed t...

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Veröffentlicht in:	Bioengineering (Basel) 2021-12, Vol.8 (12), p.211, Article 211
Hauptverfasser:	Josephine Boder, E., Banerjee, Ipsita A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal models Apolipoproteins Bioengineering biomimetics Biotechnology & Applied Microbiology Blood vessels Brain research Cell culture Cell differentiation Clinical trials Dementia disorders Differentiation (biology) Drug screening Engineering Engineering, Biomedical FDA approval Genes Hypotheses In vivo methods and tests Life Sciences & Biomedicine Microfluidic devices microphysiological systems Mutation Neurodegenerative diseases Organoids Pathogenesis Pathology Pathophysiology Patients Peptides Physiology Pluripotency Proteins Review Science & Technology Stem cell transplantation Stem cells Technology Transgenic mice
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