Bladder infection with uropathogenic Escherichia coli increases the excitability of afferent neurons

Urinary tract infections (UTIs) cause bladder hyperactivity and pelvic pain, but the underlying causes of these symptoms remain unknown. We investigated whether afferent sensitization contributes to the bladder overactivity and pain observed in mice suffering from experimentally induced bacterial cy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2022-01, Vol.322 (1), p.F1-F13
Hauptverfasser:	Montalbetti, Nicolas, Dalghi, Marianela G, Bastacky, Sheldon I, Clayton, Dennis R, Ruiz, Wily G, Apodaca, Gerard, Carattino, Marcelo D
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials Animals Bacteria Bladder Cystitis, Interstitial - microbiology Cystitis, Interstitial - physiopathology Disease Models, Animal E coli Edema Escherichia coli Escherichia coli Infections - microbiology Escherichia coli Infections - physiopathology Excitability Female Hyperactivity Inflammation Inoculation Lipopolysaccharides Membrane potential Mice Mice, Inbred C57BL Mucosa Neurons, Afferent - metabolism Pain Pain perception Sensory neurons Tetrodotoxin Urinary Bladder - innervation Urinary Bladder - microbiology Urinary tract Urinary tract infections Urinary Tract Infections - microbiology Urinary Tract Infections - physiopathology Urodynamics Urogenital system Uropathogenic Escherichia coli - metabolism Uropathogenic Escherichia coli - pathogenicity Virulence Virulence factors Virulence Factors - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!