Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit

Current treatment options for ovarian clear cell carcinoma (OCCC) are limited to combination of platinum-based and other cytotoxic agents to which patients respond poorly due to intrinsic chemoresistance. There is therefore an urgent need to develop alternative therapeutic strategies for OCCC. Cyste...

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Veröffentlicht in:	Antioxidants & redox signaling 2020-12, Vol.33 (17), p.1191-1208
Hauptverfasser:	Novera, Wisna, Lee, Zheng-Wei, Nin, Dawn Sijin, Dai, Melvin Zi-Yu, Binte Idres, Shabana, Wu, Hui, Damen, J Mirjam A, Tan, Tuan Zea, Sim, Arthur Yi Loong, Long, Yun Chau, Wu, Wei, Huang, Ruby Yun-Ju, Deng, Lih-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Clear Cell - metabolism Apoptosis Biocompatibility Bioenergetics Cancer Therapy (Ed. Gautam Sethi)—Part B Cell death Cell Survival Chemoresistance Clusters Cysteine Cysteine - metabolism Cytotoxic agents Cytotoxicity Deprivation Electron transport Electron transport chain Female Ferroptosis Forum Original Research Communication Glutathione - metabolism Glycolysis Humans In vivo methods and tests Iron Iron - metabolism Metabolism Mitochondria Mitochondria - metabolism Models, Biological Necrosis Necrosis - metabolism Ovarian Neoplasms - metabolism Ovaries Oxidative Stress Platinum Pretreatment Respiration Sulfur Sulfur - metabolism Toxicity
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