Fibroblast to myofibroblast transition is enhanced by increased cell density

Idiopathic pulmonary fibrosis (IPF) is a chronic disease of the lung caused by a rampant inflammatory response that results in the deposition of excessive extracellular matrix (ECM). IPF patient lungs also develop fibroblastic foci that consist of activated fibroblasts and myofibroblasts. In concert...

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Veröffentlicht in:Molecular biology of the cell 2021-12, Vol.32 (22), p.ar41-ar41
Hauptverfasser: Doolin, Mary T, Smith, Ian M, Stroka, Kimberly M
Format: Artikel
Sprache:eng
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