Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast

Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute to chromosomal instability (CIN), which has been observed in many diseases including cancer. Epigenetic regulation of kinetochore proteins such as Cse4 (CENP-A in humans) plays a critical role in hig...

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Veröffentlicht in:	Molecular biology of the cell 2021-11, Vol.32 (21), p.ar15-ar15
Hauptverfasser:	Mishra, Prashant K, Wood, Henry, Stanton, John, Au, Wei-Chun, Eisenstatt, Jessica R, Boeckmann, Lars, Sclafani, Robert A, Weinreich, Michael, Bloom, Kerry S, Thorpe, Peter H, Basrai, Munira A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Centromere - metabolism Centromere Protein A - metabolism Chromatin - metabolism Chromosomal Instability Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomal Proteins, Non-Histone - physiology Chromosome Segregation - physiology Chromosomes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Epigenesis, Genetic Histones - metabolism Kinetochores - metabolism Nuclear Proteins - metabolism Phosphorylation Protein Serine-Threonine Kinases - metabolism Protein Serine-Threonine Kinases - physiology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - physiology
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