Genomic Determinants of Clinical Outcomes in Rhabdomyosarcoma

Increased availability of next-generation sequencing has allowed for the genomic characterization of a variety of pediatric tumors, although genomic determinants of response to treatment remain largely unknown. We sought to evaluate the genomic landscape and genomic determinants of clinical outcomes...

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Veröffentlicht in:	Clinical cancer research 2020-03, Vol.26 (5), p.1135-1140
Hauptverfasser:	Casey, Dana L, Wexler, Leonard H, Pitter, Kenneth L, Samstein, Robert M, Slotkin, Emily K, Wolden, Suzanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biomarkers, Tumor - genetics Child Child, Preschool Female High-Throughput Nucleotide Sequencing - methods Humans Infant Male Middle Aged Molecular Targeted Therapy Mutation Oncogene Proteins, Fusion - genetics Prognosis Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - genetics Rhabdomyosarcoma - mortality Rhabdomyosarcoma - pathology Survival Rate Tumor Suppressor Protein p53 - genetics Young Adult
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