Molecular mechanisms of dietary restriction promoting health and longevity

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and extending healthspan and lifespan in diverse species, including rodents and non-human primates. In this Review, we discuss the effects of dietary restriction in these mammalian model organisms and discuss accumu...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2022-01, Vol.23 (1), p.56-73
Hauptverfasser:	Green, Cara L., Lamming, Dudley W., Fontana, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/443/7 631/80/304 Adenine Aging AKT protein Amino acids AMP-activated protein kinase Animals Bioaccumulation Biochemistry Biomedical and Life Sciences Caloric Restriction Cancer Research Cell Biology Chain branching Developmental Biology Dietary restrictions Disease Models, Animal Fibroblast growth factors Forkhead protein Growth factors Health Health promotion Humans Kinases Life Sciences Life span Longevity Longevity - physiology Metabolism Methionine Molecular modelling NAD Nicotinamide Nicotinamide adenine dinucleotide Nutrients Nutrition Oxidative Stress Prevention Primates Proteins Review Article Rodents Signal transduction Signaling Species diversity Stem Cells TOR protein
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