Urban Particulate Matter Impairment of Airway Surface Liquid–Mediated Coronavirus Inactivation

Abstract Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV...

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Veröffentlicht in:	The Journal of infectious diseases 2022-01, Vol.225 (2), p.214-218
Hauptverfasser:	Stapleton, Emma M, Welch, Jennifer L, Ubeda, Erika A, Xiang, Jinhua, Zabner, Joseph, Thornell, Ian M, Nonnenmann, Matthew W, Stapleton, Jack T, Comellas, Alejandro P
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Antiviral activity Antiviral Agents - pharmacology Antiviral drugs Coronavirus 229E, Human Coronaviruses COVID-19 - prevention & control COVID-19 - transmission Epithelial cells Humans Immunity, Innate Indoor air quality Infections Major and Brief Reports Particulate matter Particulate Matter - adverse effects Polymerase Chain Reaction Respiratory tract SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Urban Health Urban Population Volcanic ash
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