Pegbelfermin selectively reduces secondary bile acid concentrations in patients with non-alcoholic steatohepatitis

Increased serum bile acids (BAs) have been observed in patients with non-alcoholic steatohepatitis (NASH). Pegbelfermin (PGBF), a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21), significantly decreased hepatic steatosis and improved fibrosis biomarkers...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	JHEP reports 2022-01, Vol.4 (1), p.100392-100392, Article 100392
Hauptverfasser:	Luo, Yi, Decato, Benjamin E., Charles, Edgar D., Shevell, Diane E., McNaney, Colleen, Shipkova, Petia, Apfel, Abraham, Tirucherai, Giridhar S., Sanyal, Arun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile salt hydrolase Biomarkers Deoxycholic acid FGF21 Microbiome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!