Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca2+ release during excitation–contraction (EC) coupling in muscle. The NTR hosts numerous mutations linked to skeletal (RyR1) and cardiac (RyR2) myopathies, highlighting its potential as a therapeutic...

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Veröffentlicht in:	The Journal of biological chemistry 2022-01, Vol.298 (1), p.101412-101412, Article 101412
Hauptverfasser:	Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip, Cornea, Razvan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques Calcium - metabolism fluorescence lifetime Fluorescence Resonance Energy Transfer FRET high-throughput screening High-Throughput Screening Assays Mice Muscle, Skeletal - chemistry Muscle, Skeletal - metabolism myopathy N-terminal region ryanodine receptor Ryanodine Receptor Calcium Release Channel - analysis Ryanodine Receptor Calcium Release Channel - metabolism
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