Reciprocal regulation of chaperone-mediated autophagy and the circadian clock

Circadian rhythms align physiological functions with the light–dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here we sh...

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Veröffentlicht in:	Nature cell biology 2021-12, Vol.23 (12), p.1255-1270
Hauptverfasser:	Juste, Yves R., Kaushik, Susmita, Bourdenx, Mathieu, Aflakpui, Ranee, Bandyopadhyay, Sanmay, Garcia, Fernando, Diaz, Antonio, Lindenau, Kristen, Tu, Vincent, Krause, Gregory J., Jafari, Maryam, Singh, Rajat, Muñoz, Javier, Macian, Fernando, Cuervo, Ana Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/51 14/19 14/35 38 38/77 42 631/80/105 631/80/39/2345 64/60 82/29 Adaptability Aging Aging - physiology Animals ARNTL Transcription Factors - genetics Autophagy Autophagy (Cytology) Biological clocks Biomedical and Life Sciences Cancer Research Cell Biology Chaperone-Mediated Autophagy - physiology Circadian Clocks - physiology Circadian rhythm Circadian Rhythm - physiology Circadian rhythms CLOCK Proteins - metabolism Developmental Biology Disruption Genetic aspects Life Sciences Lysosomal-Associated Membrane Protein 2 - genetics Lysosomes - chemistry Male Mice Mice, Inbred C57BL Mice, Knockout Molecular chaperones Phagocytosis Photoperiod Physiological aspects Proteins Proteolysis Proteome - genetics Proteomes Proteostasis - physiology Sleep Deprivation - physiopathology Sleep disorders Stem Cells Transcription Transcription, Genetic - genetics
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