ADAMTSL2 protein and a soluble biomarker signature identify significant and advanced fibrosis in adults with NAFLD

ADAMTSL2 protein and a soluble biomarker signature identify significant and advanced fibrosis in adults with NAFLD

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease worldwide. Diagnosing NAFLD and identifying fibrosis (scarring of the liver) currently requires a liver biopsy. Our study identified novel proteins found in blood which may identify fibrosis without the need...

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Veröffentlicht in:Journal of hepatology 2021-10, Vol.76 (1), p.25-33
Hauptverfasser: Corey, Kathleen E., Pitts, Rebecca, Lai, Michelle, Loureiro, Joseph, Masia, Ricard, Osganian, Stephanie A., Gustafson, Jenna L., Hutter, Matthew M., Gee, Denise W., Meireles, Ozanan R., Witkowski, Elan R., Richards, Shola M., Jacob, Jaison, Finkel, Nancy, Ngo, Debby, Wang, Thomas J, Gerszten, Robert E., Ukomadu, Chinweike, Jennings, Lori L.
Format: Artikel
Sprache:eng
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Zusammenfassung:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease worldwide. Diagnosing NAFLD and identifying fibrosis (scarring of the liver) currently requires a liver biopsy. Our study identified novel proteins found in blood which may identify fibrosis without the need for a liver biopsy.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2021.09.026