ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF βTrCP Ubiquitin Ligase

The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box protein βTrCP, the receptor component of the SCF E3 ubiquitin ligase responsible for IκBα and β-catenin degradation, is colocalized in the nucleus with ATF4, a member of the ATF-CREB b...

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Veröffentlicht in:	Molecular and cellular biology 2001-03, Vol.21 (6), p.2192-2202
Hauptverfasser:	Lassot, Irina, Ségéral, Emmanuel, Berlioz-Torrent, Clarisse, Durand, Herve, Groussin, Lionel, Hai, Tsonwin, Benarous, Richard, Margottin-Goguet, Florence
Format:	Artikel
Sprache:	eng
Schlagworte:	Transcriptional Regulation
Online-Zugang:	Volltext
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