Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells

Histone deacetylase inhibitors, such as valproic acid (VPA), have important clinical therapeutic and cellular reprogramming applications. They induce chromatin reorganization that is associated with altered cellular morphology. However, there is a lack of comprehensive characterization of VPA-induce...

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Veröffentlicht in:	Molecular biology of the cell 2021-08, Vol.32 (18), p.1624-1633
Hauptverfasser:	Kalinin, Alexandr A, Hou, Xinhai, Ade, Alex S, Fon, Gordon-Victor, Meixner, Walter, Higgins, Gerald A, Sexton, Jonathan Z, Wan, Xiang, Dinov, Ivo D, O'Meara, Matthew J, Athey, Brian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes - drug effects Astrocytes - physiology Brief Reports Cell Nucleus - drug effects Cell Nucleus - physiology Cells, Cultured Histone Deacetylase Inhibitors - pharmacology Humans Image Processing, Computer-Assisted Time Factors Valproic Acid - pharmacology
Online-Zugang:	Volltext
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